Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS
mobile menu button

Search

Page Path
HOME > Search
10 "Yongin Cho"
Filter
Filter
Article category
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
Original Articles
Complications
Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression Risk in Patients with Type 2 Diabetes Mellitus
Yongin Cho, Hye-Sun Park, Byung Wook Huh, Yong-ho Lee, Seong Ha Seo, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, So Hun Kim
Diabetes Metab J. 2023;47(2):232-241.   Published online January 19, 2023
DOI: https://doi.org/10.4093/dmj.2021.0355
  • 3,629 View
  • 222 Download
  • 1 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We aimed to evaluate whether non-alcoholic fatty liver disease (NAFLD) with or without sarcopenia is associated with progression of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
Methods
We investigated 852 T2DM patients who underwent abdominal ultrasonography, bioelectrical impedance analysis, and carotid artery ultrasonography at baseline and repeated carotid ultrasonography after 6 to 8 years. NAFLD was confirmed by abdominal ultrasonography, and sarcopenia was defined as a sex-specific skeletal muscle mass index (SMI) value <2 standard deviations below the mean for healthy young adults. SMI was calculated by dividing the sum of appendicular skeletal mass by body weight. We investigated the association between NAFLD with or without sarcopenia and the progression of carotid atherosclerosis.
Results
Of the 852 patients, 333 (39.1%) were classified as NAFLD without sarcopenia, 66 (7.7%) were classified as sarcopenia without NAFLD, and 123 (14.4%) had NAFLD with sarcopenia at baseline. After 6 to 8 years, patients with both NAFLD and sarcopenia had a higher risk of atherosclerosis progression (adjusted odds ratio, 2.20; P<0.009) than controls without NAFLD and sarcopenia. When a subgroup analysis was performed on only patients with NAFLD, female sex, absence of central obesity, and non-obesity were significant factors related to increased risk of plaque progression risk in sarcopenic patients.
Conclusion
NAFLD with sarcopenia was significantly associated with the progression of carotid atherosclerosis in T2DM patients.

Citations

Citations to this article as recorded by  
  • Metabolic-associated fatty liver disease and sarcopenia: A double whammy
    Aditya Viswanath, Sherouk Fouda, Cornelius James Fernandez, Joseph M Pappachan
    World Journal of Hepatology.2024; 16(2): 152.     CrossRef
  • Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease
    Suprabhat Giri, Prajna Anirvan, Sumaswi Angadi, Ankita Singh, Anurag Lavekar
    World Journal of Gastrointestinal Pathophysiology.2024;[Epub]     CrossRef
  • Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis
    Manouchehr Khoshbaten, Sepideh H. Maleki, Sara Hadad, Amrit Baral, Ana V. Rocha, Laxmi Poudel, Alireza Abdshah
    Health Science Reports.2023;[Epub]     CrossRef
  • Cardiometabolic risk factors in patients with type 2 diabetes and sarcopenia
    Yu. G. Samoilova, M. V. Matveeva, E. A. Khoroshunova, D. V. Podchinenova, L. L. Maksimova, G. G. Gorbach, A. B. Trivozhenko, V. A. Avkhimenko
    Cardiovascular Therapy and Prevention.2023; 23(1): 3655.     CrossRef
Complications
Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
Da Hea Seo, Young Ju Suh, Yongin Cho, Seong Hee Ahn, Seongha Seo, Seongbin Hong, Yong-ho Lee, Young Ju Choi, Eunjig Lee, So Hun Kim
Diabetes Metab J. 2022;46(4):630-639.   Published online January 26, 2022
DOI: https://doi.org/10.4093/dmj.2021.0130
  • 5,578 View
  • 274 Download
  • 14 Web of Science
  • 16 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Nonalcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). However, the causal relationship between NAFLD and CKD is uncertain, particularly in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the association between the presence and severity of NAFLD and incident CKD in patients with T2DM.
Methods
In this longitudinal cohort study of patients with T2DM, 3,188 patients with preserved renal function were followed up for the occurrence of incident CKD. NAFLD was defined as the presence of hepatic steatosis on ultrasonography, without any other causes of chronic liver disease. Advanced liver fibrosis of NAFLD was defined as a fibrosis-4 index ≥2.67. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2.
Results
At baseline, 1,729 (54.2%) patients had NAFLD, of whom 94 (5.4%) had advanced liver fibrosis. During the follow-up of 8.3±3.6 years, 472 (14.8%) patients developed incident CKD: 220 (15.1%) in the non-NAFLD group, 231 (14.1%) in the NAFLD without advanced fibrosis group and 28 (31.1%) in the NAFLD with advanced fibrosis group. There was no increased risk of incident CKD in the NAFLD group compared to the non-NAFLD group (P=0.435). However, among patients with NAFLD, advanced liver fibrosis was associated with an increased risk of CKD (adjusted hazard ratio, 1.75; 95% confidence interval, 1.15 to 2.66; P=0.009).
Conclusion
Advanced liver fibrosis in patients with NAFLD is independently associated with an increased risk of incident CKD in patients with T2DM.

Citations

Citations to this article as recorded by  
  • Esteatosis hepática metabólica y nefropatía diabética: una llamada a la acción
    Salvador Benlloch, Francesc Moncho, Jose Luis Górriz
    Nefrología.2024; 44(2): 129.     CrossRef
  • Longitudinal Outcomes Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Meta-analysis of 129 Studies
    Kai En Chan, Elden Yen Hng Ong, Charlotte Hui Chung, Christen En Ya Ong, Benjamin Koh, Darren Jun Hao Tan, Wen Hui Lim, Jie Ning Yong, Jieling Xiao, Zhen Yu Wong, Nicholas Syn, Apichat Kaewdech, Margaret Teng, Jiong-Wei Wang, Nicholas Chew, Dan Yock Young
    Clinical Gastroenterology and Hepatology.2024; 22(3): 488.     CrossRef
  • Association of NAFLD/NASH, and MAFLD/MASLD with chronic kidney disease: an updated narrative review
    Amedeo Lonardo
    Metabolism and Target Organ Damage.2024;[Epub]     CrossRef
  • Targeting metabolic-associated fatty liver disease in diabetic kidney disease: A call to action
    Salvador Benlloch, Francesc Moncho, Jose Luis Górriz
    Nefrología (English Edition).2024;[Epub]     CrossRef
  • MAFLD and NAFLD in the prediction of incident chronic kidney disease
    So Yoon Kwon, Jiyun Park, So Hee Park, You-Bin Lee, Gyuri Kim, Kyu Yeon Hur, Janghyun Koh, Jae Hwan Jee, Jae Hyeon Kim, Mira Kang, Sang-Man Jin
    Scientific Reports.2023;[Epub]     CrossRef
  • Associations of non-invasive indices of liver steatosis and fibrosis with progressive kidney impairment in adults with type 2 diabetes
    Mei Chung Moh, Sharon Li Ting Pek, Kenny Ching Pan Sze, Serena Low, Tavintharan Subramaniam, Keven Ang, Wern Ee Tang, Simon Biing Ming Lee, Chee Fang Sum, Su Chi Lim
    Acta Diabetologica.2023; 60(6): 827.     CrossRef
  • Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance
    Verena Damiani, Alessia Lamolinara, Ilaria Cicalini, Maria Concetta Cufaro, Francesco Del Pizzo, Federica Di Marco, Piero Del Boccio, Beatrice Dufrusine, Michael Hahne, Rossano Lattanzio, Damiana Pieragostino, Manuela Iezzi, Massimo Federici, Maria Cateri
    Molecular Metabolism.2023; 74: 101752.     CrossRef
  • Utility of non-invasive liver fibrosis markers to predict the incidence of chronic kidney disease (CKD): A systematic review, meta-analysis, and meta-regression
    Rudi Supriyadi, Theo Audi Yanto, Timotius Ivan Hariyanto, Ketut Suastika
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(8): 102814.     CrossRef
  • Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease
    Jaehyun Bae, Byung-Wan Lee
    Biomedicines.2023; 11(7): 1928.     CrossRef
  • Hepatic Fibrosis Evaluated in Patients with Type 2 Diabetes with and without Chronic Kidney Disease
    Therese Adrian, Mads Hornum, Filip Krag Knop, Karl Bang Christensen, Thomas Almdal, Peter Rossing, Lisa Í Lídaa, Niels Søndergaard Heinrich, Vincent Oltman Boer, Anouk Marsman, Esben Thade Petersen, Hartwig Roman Siebner, Bo Feldt-Rasmussen
    Nephron.2023; 147(11): 673.     CrossRef
  • Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19
    Olivier Deckmyn, Thierry Poynard, Pierre Bedossa, Valérie Paradis, Valentina Peta, Raluca Pais, Vlad Ratziu, Dominique Thabut, Angelique Brzustowski, Jean-François Gautier, Patrice Cacoub, Dominique Valla
    Biomedicines.2022; 10(3): 699.     CrossRef
  • Fibrosis Risk in Nonalcoholic Fatty Liver Disease Is Related to Chronic Kidney Disease in Older Type 2 Diabetes Patients
    Yifan Sun, Liang Hong, Zhe Huang, Lihong Wang, Yanqin Xiong, Shuhang Zong, Rui Zhang, Jun Liu, Shufei Zang
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(9): e3661.     CrossRef
  • Beyond Liver Disease: Non-Alcoholic Fatty Liver Disease and Advanced Liver Fibrosis in Kidney Disease
    Eugene Han
    Diabetes & Metabolism Journal.2022; 46(4): 564.     CrossRef
  • A higher FIB‐4 index is associated with an increased incidence of renal failure in the general population
    Eva Maria Schleicher, Simon Johannes Gairing, Peter Robert Galle, Julia Weinmann‐Menke, Jörn M. Schattenberg, Karel Kostev, Christian Labenz
    Hepatology Communications.2022; 6(12): 3505.     CrossRef
  • Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease (Diabetes Metab J 2022;46:630-9)
    Ji Hye Huh
    Diabetes & Metabolism Journal.2022; 46(6): 953.     CrossRef
  • Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease (Diabetes Metab J 2022;46:630-9)
    Da Hea Seo, So Hun Kim
    Diabetes & Metabolism Journal.2022; 46(6): 956.     CrossRef
Guideline/Fact Sheet
Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Jae-Seung Yun, Sun Young Kim, Sung Rae Kim, In-Kyung Jeong, Ji-Oh Mok, Kun Ho Yoon
Diabetes Metab J. 2021;45(1):1-10.   Published online January 13, 2021
DOI: https://doi.org/10.4093/dmj.2020.0254
  • 21,726 View
  • 1,155 Download
  • 131 Web of Science
  • 160 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study aimed to investigate the recent prevalence, management, and comorbidities of diabetes among Korean adults aged ≥30 years by analyzing nationally representative data.
Methods
This study used data from the Korea National Health and Nutrition Examination Survey from 2016 to 2018, and the percentage and total number of people ≥30 years of age with diabetes and impaired fasting glucose (IFG) were estimated.
Results
In 2018, 13.8% of Korean adults aged ≥30 years had diabetes, and adults aged ≥65 years showed a prevalence rate of 28%. The prevalence of IFG was 26.9% in adults aged ≥30 years. From 2016 to 2018, 35% of the subjects with diabetes were not aware of their condition. Regarding comorbidities, 53.2% and 61.3% were obese and hypertensive, respectively, and 72% had hypercholesterolemia as defined by low-density lipoprotein cholesterol (LDL-C) ≥100 mg/dL in people with diabetes. Of the subjects with diabetes, 43.7% had both hypertension and hypercholesterolemia. With regard to glycemic control, only 28.3% reached the target level of <6.5%. Moreover, only 11.5% of subjects with diabetes met all three targets of glycosylated hemoglobin, blood pressure, and LDL-C. The percentage of energy intake from carbohydrates was higher in diabetes patients than in those without diabetes, while that from protein and fat was lower in subjects with diabetes.
Conclusion
The high prevalence and low control rate of diabetes and its comorbidities in Korean adults were confirmed. More stringent efforts are needed to improve the comprehensive management of diabetes to reduce diabetes-related morbidity and mortality.

Citations

Citations to this article as recorded by  
  • 호남권 지역주민의 건강행태와 만성질환 관리현황
    선아 김, 정은 이
    Public Health Weekly Report.2024; 17(2): 46.     CrossRef
  • Variability in the association of smoking status with the prevalence of diabetes mellitus in the Korean population according to different definitions of smoking status: analysis based on the Korea National Health and Nutrition Examination Survey (2014-202
    Yechan Kyung, Young Sook Park, Mi Hyeon Jin, Hae Jeong Lee
    International Journal of Environmental Health Research.2024; : 1.     CrossRef
  • Factors Influencing the Dietary Behavior of Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study
    Sohyun Jin, Youngshin Song
    Journal of Korean Academy of Fundamentals of Nursing.2024; 31(1): 80.     CrossRef
  • Analysis of dietary behavior and intake related to glycemic control in patients with type 2 diabetes aged 30 years or older in Korea: Utilizing the 8th Korea National Health and Nutrition Examination Survey (2019–2021)
    Jin-Ah Seok, Yeon-Kyung Lee
    Nutrition Research and Practice.2024; 18(2): 239.     CrossRef
  • Effects of an Electronic Medical Records-Linked Diabetes Self-Management System on Treatment Targets in Real Clinical Practice: Retrospective, Observational Cohort Study
    So Jung Yang, Sun-Young Lim, Yoon Hee Choi, Jin Hee Lee, Kun-Ho Yoon
    Endocrinology and Metabolism.2024; 39(2): 364.     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • The evolution and future of diagnostic criteria for diabetes mellitus
    Eun-Jung Rhee
    Journal of the Korean Medical Association.2023; 66(7): 409.     CrossRef
  • Efficacy of intermittent short‐term use of a real‐time continuous glucose monitoring system in non‐insulin–treated patients with type 2 diabetes: A randomized controlled trial
    Sun Joon Moon, Kyung‐Soo Kim, Woo Je Lee, Mi Yeon Lee, Robert Vigersky, Cheol‐Young Park
    Diabetes, Obesity and Metabolism.2023; 25(1): 110.     CrossRef
  • Ocular motility disorders following coronavirus disease-19 vaccination
    Kyung-Ah Park, Hyeshin Jeon, Dong Gyu Choi, Jae Ho Jung, Hyun-Jin Shin, Byung Joo Lee, Yeji Moon, Se-Youp Lee, Dong Cheol Lee, Soon Young Cho, Seong-Joon Kim, Sei Yeul Oh, Sunghyuk Moon, Shin Yeop Oh, Daye Diana Choi, Mi Young Choi, Won Jae Kim, Ungsoo Sa
    Graefe's Archive for Clinical and Experimental Ophthalmology.2023; 261(4): 1127.     CrossRef
  • Comorbidities associated with high-risk obstructive sleep apnea based on the STOP-BANG questionnaire: a nationwide population-based study
    Gene Huh, Kyoung do Han, Yong-Moon Park, Chan-Soon Park, Kyu-na Lee, Eun Young Lee, Jung-Hae Cho
    The Korean Journal of Internal Medicine.2023; 38(1): 80.     CrossRef
  • Low Skeletal Muscle Mass Accompanied by Abdominal Obesity Additively Increases the Risk of Incident Type 2 Diabetes
    Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hwan Jee, Jae Hyeon Kim
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(5): 1173.     CrossRef
  • Threshold dose–response association between smoking pack-years and the risk of gallbladder cancer: A nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    European Journal of Cancer.2023; 180: 99.     CrossRef
  • Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes
    Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
    The Korean Journal of Internal Medicine.2023; 38(1): 93.     CrossRef
  • Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study
    Bukyung Kim, Hak Sung Lee, Hye-Jin Kim, Hyolynn Lee, In-young Lee, Soyoung Ock, Sukyoung Kwon, Sang-Soo Kang, Youngsik Choi
    Food Science and Biotechnology.2023; 32(5): 697.     CrossRef
  • Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh: Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)
    Sabiha Shirin Sara, Ashis Talukder, Ka Yiu Lee, Nayan Basak, Shaharior Rahman Razu, Iqramul Haq, Chuton Deb Nath
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(2): 102706.     CrossRef
  • Effectiveness of Non-Contact Dietary Coaching in Adults with Diabetes or Prediabetes Using a Continuous Glucose Monitoring Device: A Randomized Controlled Trial
    Yeh-Chan Ahn, Yang Seok Kim, Bukyung Kim, Jung Mi Ryu, Myoung Soo Kim, Minkyeong Kang, Jiwon Park
    Healthcare.2023; 11(2): 252.     CrossRef
  • Interactions between Bitter Taste Receptor Gene Variants and Dietary Intake Are Associated with the Incidence of Type 2 Diabetes Mellitus in Middle-Aged and Older Korean Adults
    Kyung Won Lee, Dayeon Shin
    International Journal of Molecular Sciences.2023; 24(3): 2199.     CrossRef
  • Relationship between age at menarche and metabolic diseases in Korean postmenopausal women: The Korea National Health and Nutrition Examination Survey 2016–2018
    Hyein Jung, Yeon-Ah Sung, Young Sun Hong, Do Kyeong Song, So-hyeon Hong, Hyejin Lee, Tatsuo Shimosawa
    PLOS ONE.2023; 18(1): e0280929.     CrossRef
  • Safety and Effectiveness of Empagliflozin in Korean Patients with Type 2 Diabetes Mellitus: Results from a Nationwide Post-Marketing Surveillance
    Jun Sung Moon, Nam Hoon Kim, Jin Oh Na, Jae Hyoung Cho, In-Kyung Jeong, Soon Hee Lee, Ji-Oh Mok, Nan Hee Kim, Dong Jin Chung, Jinhong Cho, Dong Woo Lee, Sun Woo Lee, Kyu Chang Won
    Diabetes & Metabolism Journal.2023; 47(1): 82.     CrossRef
  • Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis
    Shanhu Qiu, Xue Cai, Yan Liang, Wenji Chen, Duolao Wang, Zilin Sun, Bo Xie, Tongzhi Wu
    Diabetes Research and Clinical Practice.2023; 197: 110562.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • Consistency of 1-day and 3-day average dietary intake and the relationship of dietary intake with blood glucose, hbA1c, BMI, and lipids in patients with type 2 diabetes
    DaeEun Lee, Haejung Lee, Sangeun Lee, MinJin Lee, Ah Reum Khang
    Journal of Korean Biological Nursing Science.2023; 25(1): 20.     CrossRef
  • Systematic literature review and meta-analysis of cardiovascular risk factor management in selected Asian countries
    Eric J Yeh, Ruth Bartelli Grigolon, Sarah Ramalho Rodrigues, Ana Paula A Bueno
    Journal of Comparative Effectiveness Research.2023;[Epub]     CrossRef
  • Gut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy
    Ji Eun Kim, Hoonsik Nam, Ji In Park, Hyunjeong Cho, Jangwook Lee, Hyo-Eun Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong-Soo Kim, Sunghyouk Park, Hajeong Lee, Jan Claesen
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Prevalence and associated factors of diabetes mellitus among patients with tuberculosis in South Korea from 2011 to 2018: a nationwide cohort study
    Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Jeong Mi Seo, Hongjo Choi, Young Ae Kang
    BMJ Open.2023; 13(3): e069642.     CrossRef
  • Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
    Kyung-Soo Kim, Kyung Ah Han, Tae Nyun Kim, Cheol-Young Park, Jung Hwan Park, Sang Yong Kim, Yong Hyun Kim, Kee Ho Song, Eun Seok Kang, Chul Sik Kim, Gwanpyo Koh, Jun Goo Kang, Mi Kyung Kim, Ji Min Han, Nan Hee Kim, Ji Oh Mok, Jae Hyuk Lee, Soo Lim, Sang S
    Diabetes & Metabolism.2023; 49(4): 101440.     CrossRef
  • Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
    Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
    PLOS ONE.2023; 18(3): e0283023.     CrossRef
  • Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes
    Salma Nabila, Ji-Eun Kim, Jaesung Choi, JooYong Park, Aesun Shin, Sang-Ah Lee, Jong-koo Lee, Daehee Kang, Ji-Yeob Choi
    Diabetes Care.2023; 46(3): 535.     CrossRef
  • Effect of diabetes-specific oral nutritional supplements with allulose on weight and glycemic profiles in overweight or obese type 2 diabetic patients
    Jihye Tak, Minkyung Bok, Hyunkyung Rho, Ju Hyun Park, Yunsook Lim, Suk Chon, Hyunjung Lim
    Nutrition Research and Practice.2023; 17(2): 241.     CrossRef
  • The effects of hemp seed consumption on depression, anxiety and cognitive improvement based on machine learning
    Jung Jea-Bum, Cho Yong-Won , Kim Sang-Yub , Chung Soo-Yeon , Han Kyung-Hoon , Ham Byung-Joo , Han Sung-Hee
    Archives of Food and Nutritional Science.2023; 7(1): 032.     CrossRef
  • Development and Adaptability of Smartphone-based Dietary Coaching Program for Patients Undergoing Diabetes and Prediabetes with Continuous Glucose Monitoring Device
    Myoung Soo Kim, Jung Mi Ryu, Minkyeong Kang, Jiwon Park, Yeh Chan Ahn, Yang Seok Kim
    Journal of Health Informatics and Statistics.2023; 48(1): 36.     CrossRef
  • Risk of Diabetic Complications in Type 2 Diabetes Patients with Dementia: A Population-Based Study Using National Health Insurance Claims Data
    Eun Sik Jeong, Ah-Young Kim, Hye-Young Kang
    Drug Targets and Therapeutics.2023; 2(1): 49.     CrossRef
  • Type 2 Diabetes Mellitus- and Complication-Related Risk of Nontuberculous Mycobacterial Disease in a South Korean Cohort
    Da Som Jeon, Seonok Kim, Mi Ae Kim, Yong Pil Chong, Tae Sun Shim, Chang Hee Jung, Ye-Jee Kim, Kyung-Wook Jo, Paschalis Vergidis, Byung Woo Jhun
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study
    Geun Woo Lee, Chul Ho Lee, Seong Gyu Kim
    Journal of Yeungnam Medical Science.2023; 40(2): 146.     CrossRef
  • RELATIVE RISK OF DIABETES MELLITUS AMONG OBESE POPULATION
    Umair Khalid, Khuram Chaudry, Hina Khuram
    Pakistan Journal of Rehabilitation.2023; 12(1): 93.     CrossRef
  • Public–Private Partnership: Participants’ Experiences of the Web-Based Registration-and-Management System for Patients with Hypertension and Diabetes Mellitus
    Seonah Lee, Nanyoung Song, Suhyun Kim
    Healthcare.2023; 11(9): 1297.     CrossRef
  • Anti-Hyperglycemic Effects of Fermented Mealworm Extract on Type 2 Diabetic Mice
    Hae-In Lee, Asli Turkyilmaz, Mi-Kyung Lee
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(4): 431.     CrossRef
  • A Study on Changes in Nutritional and Blood Conditions Before and After Consumption of Diabetic Soymilk in Elderly Women with Diabetes
    Hyo-Jeong Hwang, Soon-Hee Park, Seon-Young Park, Soo-Rin Ahn, Su-Jin Park, Yoo-Jin Lee, Kwang-Jin Chon, Chung-Hwa Song, Dae-Gyun Moon, Kyung-Ok Shin
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(4): 341.     CrossRef
  • Developing a Classification Algorithm for Prediabetes Risk Detection From Home Care Nursing Notes
    Eunjoo Jeon, Aeri Kim, Jisoo Lee, Hyunsook Heo, Hana Lee, Kyungmi Woo
    CIN: Computers, Informatics, Nursing.2023; 41(7): 539.     CrossRef
  • Chronic disease management program applied to type 2 diabetes patients and prevention of diabetic complications: a retrospective cohort study using nationwide data
    Min Kyung Hyun, Jang Won Lee, Seung-Hyun Ko
    BMC Public Health.2023;[Epub]     CrossRef
  • Peripheral neuropathy and neuropathic pain in the elderly
    Je-Young Shin
    Journal of Geriatric Neurology.2023; 2(1): 7.     CrossRef
  • Cholecystectomy Increases the Risk of Type 2 Diabetes in the Korean Population
    Ji Hye Huh, Kyong Joo Lee, Yun Kyung Cho, Shinje Moon, Yoon Jung Kim, Eun Roh, Kyung-do Han, Dong Hee Koh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
    Annals of Surgery.2023; 278(2): e264.     CrossRef
  • A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes
    Chen-Wei Lin, Yuan-Hsiung Tsai, Yun-Shing Peng, Jen-Tsung Yang, Yen-Pei Lu, Mei-Yen Chen, Chun-Wu Tung
    Biosensors.2023; 13(7): 702.     CrossRef
  • Pharmacokinetic Comparison Between a Fixed‐Dose Combination of Empagliflozin L‐Proline/Metformin and Empagliflozin/Metformin in Healthy Korean Subjects
    HyunJoon Lee, Jae‐Yong Chung, Kyung‐Sang Yu, Shin‐Jung Park, Soyoung Lee
    Clinical Pharmacology in Drug Development.2023; 12(12): 1156.     CrossRef
  • Comparisons of the prediction models for undiagnosed diabetes between machine learning versus traditional statistical methods
    Seong Gyu Choi, Minsuk Oh, Dong–Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
    Scientific Reports.2023;[Epub]     CrossRef
  • Comparison of therapeutic efficacy and safety of sitagliptin, dapagliflozin, or lobeglitazone adjunct therapy in patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea and metformin: Third agent study
    Jun Hwa Hong, Jun Sung Moon, Kayeon Seong, Soo Lim
    Diabetes Research and Clinical Practice.2023; 203: 110872.     CrossRef
  • Predicting micropollutant fate during wastewater treatment using refined classical kinetic model based on quantitative monitoring in multi-metropolitan regions of South Korea
    Sung Ho Chae, Seung Ji Lim, Mingizem Gashaw Seid, Wondesen Workneh Ejerssa, Aseom Son, Heejong Son, Sangki Choi, Woongbae Lee, Yunho Lee, Seok Won Hong
    Water Research.2023; 245: 120627.     CrossRef
  • Intake of Fruit and Glycemic Control in Korean Patients with Diabetes Mellitus Using the Korea National Health and Nutrition Examination Survey
    Eunju Yoon, Ji Cheol Bae, Sunghwan Suh
    Endocrinology and Metabolism.2023; 38(5): 538.     CrossRef
  • Diabetes Mellitus in the Elderly Adults in Korea: Based on Data from the Korea National Health and Nutrition Examination Survey 2019 to 2020
    Seung-Hyun Ko, Kyung Do Han, Yong-Moon Park, Jae-Seung Yun, Kyuho Kim, Jae-Hyun Bae, Hyuk-Sang Kwon, Nan-Hee Kim
    Diabetes & Metabolism Journal.2023; 47(5): 643.     CrossRef
  • Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus–A Nationwide Community-based study
    Yen-Tze Liu, Wan-Hui Wu, Wei-Ting Tseng, Hsien-Chih Lin, Ming-Shiang Wu, Pei-Fen Chen, I-Chien Wu
    Journal of Psychosomatic Research.2023; 174: 111492.     CrossRef
  • Association between HbA1c and hearing loss: a tertiary care center-based study
    Hyun Jin Lee, Sung Goo Yoo, Sun Jung Lee, Jae Sang Han, In Young Choi, Kyoung Ho Park
    Scientific Reports.2023;[Epub]     CrossRef
  • The Relationship between Alcohol Consumption and Diabetes in Korean Adults
    Gi Tae Kim, Jae Woong Sull
    Biomedical Science Letters.2023; 29(3): 159.     CrossRef
  • Classification and prediction of the effects of nutritional intake on diabetes mellitus using artificial neural network sensitivity analysis: 7th Korea National Health and Nutrition Examination Survey
    Kyungjin Chang, Songmin Yoo, Simyeol Lee
    Nutrition Research and Practice.2023; 17(6): 1255.     CrossRef
  • Changes in Soluble Serum CD81 Concentration during an Oral Glucose Tolerance Test in Patients with Diabetes Mellitus and Individuals with Normal Glucose Tolerance
    Seon Mee Kang, Jun Choul Lee, Bon Jeong Ku
    Diagnostics.2023; 13(23): 3500.     CrossRef
  • Association between diabetes mellitus and cause of death in patients with tuberculosis: A Korean nationwide cohort study
    Se Hyun Kwak, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Hongjo Choi, Young Ae Kang, Frederick Quinn
    PLOS ONE.2023; 18(12): e0295556.     CrossRef
  • The development and effects of a nursing education program for hyperglycemia patient care using standardized patients for nursing students
    Jin Lee, Pok Ja Oh
    The Journal of Korean Academic Society of Nursing Education.2023; 29(4): 427.     CrossRef
  • Position Statement on the Appropriateness and Significance of Adding the Glycated Hemoglobin Test to the National Health Examination
    Ji Hye Kim, Dae Jung Kim, Jaehyun Kim, Sangjoon Park, Kyunghoon Lee, Jun Goo Kang, Eu Jeong Ku, Su Kyoung Kwon, Won Jun Kim, Young Sang Lyu, Jang Won Son, Young Sil Eom, Kyung Ae Lee, Jeongrim Lee, Jung Min Lee, Jung Hwa Lee, Jung Hwa Jung, Hochan Cho, Da
    The Journal of Korean Diabetes.2023; 24(4): 178.     CrossRef
  • An association between socioeconomic status and preventive screening for diabetic eye and kidney complications among individuals with type 2 diabetes
    Changwoo Shon, Jongnam Hwang
    Korean Journal of Health Education and Promotion.2023; 40(5): 27.     CrossRef
  • Increased risk of cancer and cancer-related mortality in middle-aged Korean women with prediabetes and diabetes: a population-based study
    Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
    Epidemiology and Health.2023; 45: e2023080.     CrossRef
  • Relationships between fasting glucose levels, lifestyle factors, and metabolic parameters in Korean adults without diagnosis of diabetes mellitus
    Seo Young Kang, Young Sik Kim
    Journal of Diabetes.2022; 14(1): 52.     CrossRef
  • Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Inae Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Min Kyong Moon
    International Journal of Hygiene and Environmental Health.2022; 240: 113886.     CrossRef
  • Trends in intake and sources of dietary protein in Korean adults, 1998–2018
    Kyung Won Lee, Dayeon Shin
    British Journal of Nutrition.2022; 128(8): 1595.     CrossRef
  • Psychometric Properties of the Korean Version of the Perceived Therapeutic Efficacy Scale for Physical Activity in Adults With Type 2 Diabetes
    Moonsun Kim, Chun-Ja Kim, Dae Jung Kim, Elizabeth A. Schlenk
    The Science of Diabetes Self-Management and Care.2022; 48(1): 11.     CrossRef
  • Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study
    Jeong Hee Chi, Bum Ju Lee, Masaki Mogi
    PLOS ONE.2022; 17(1): e0262757.     CrossRef
  • Muscle strength and prediabetes progression and regression in middle‐aged and older adults: a prospective cohort study
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Duolao Wang, Tongzhi Wu
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(2): 909.     CrossRef
  • Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study)
    Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2022; 46(1): 81.     CrossRef
  • Effect of Combined Treatment with Catechin and Quercetin on Hepatic Glucose Metabolism in Diabetic Rats
    Byoung Rai Lee, Pyoung Sim Park
    Journal of the Korean Society of Food Science and Nutrition.2022; 51(1): 12.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study (Diabetes Metab J 2021;45:675-83)
    Tae Jung Oh
    Diabetes & Metabolism Journal.2022; 46(1): 160.     CrossRef
  • East Asian perspectives in metabolic and bariatric surgery
    Tae Jung Oh, Hyuk‐Joon Lee, Young Min Cho
    Journal of Diabetes Investigation.2022; 13(5): 756.     CrossRef
  • Substitution of Carbohydrates for Fats and Risk of Type 2 Diabetes among Korean Middle-Aged Adults: Findings from the Korean Genome and Epidemiology Study
    Hye-Ah Lee, Hyesook Park
    Nutrients.2022; 14(3): 654.     CrossRef
  • Comparison of Health Outcomes by Care Provider Type for Newly Diagnosed Mild Type 2 Diabetes Patients in South Korea: A Retrospective Cohort Study
    Hee-Chung Kang, Jae-Seok Hong
    Healthcare.2022; 10(2): 334.     CrossRef
  • A deep learning model for screening type 2 diabetes from retinal photographs
    Jae-Seung Yun, Jaesik Kim, Sang-Hyuk Jung, Seon-Ah Cha, Seung-Hyun Ko, Yu-Bae Ahn, Hong-Hee Won, Kyung-Ah Sohn, Dokyoon Kim
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(5): 1218.     CrossRef
  • Rheological, textural, and functional characteristics of 3D-printed cheesecake containing guava leaf, green tea, and barley sprout powders
    Ye-Eun Park, Jeong Kim, Hyun Woo Kim, Jiyeon Chun
    Food Bioscience.2022; 47: 101634.     CrossRef
  • The Influence of Obesity and Metabolic Health on Vascular Health
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(1): 1.     CrossRef
  • Osteoporosis or fracture risk associated with thiazolidinedione and proton pump inhibitor co‐administration in patients with type 2 diabetes mellitus
    Miyoung Ock, Sera Lee, Hyunah Kim
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(7): 1028.     CrossRef
  • Differences in the gut microbiome composition of Korean children and adult samples based on different DNA isolation kits
    Changyoon Baek, Woo Jin Kim, JaeWoo Moon, Seo Yoon Moon, Wonsub Kim, Hae-Jin Hu, Junhong Min, Jonghoon Choi
    PLOS ONE.2022; 17(3): e0264291.     CrossRef
  • Association between Physical Exercise and Glycated Hemoglobin Levels in Korean Patients Diagnosed with Diabetes
    Il Yun, Hye Jin Joo, Yu Shin Park, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2022; 19(6): 3280.     CrossRef
  • Editorial: Management of Diabetes and its Complications: A Focus on Endothelial Dysfunction
    Shanhu Qiu, Jianhua Ma, Tongzhi Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The effect of long working hours on developing type 2 diabetes in adults with prediabetes: The Kangbuk Samsung Cohort Study
    Eunhye Seo, Yesung Lee, Eunchan Mun, Dae Hoon Kim, Youshik Jeong, Jaehong Lee, Jinsook Jeong, Woncheol Lee
    Annals of Occupational and Environmental Medicine.2022;[Epub]     CrossRef
  • GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions
    Ji Hee Yu, So Young Park, Da Young Lee, Nan Hee Kim, Ji A Seo
    Kidney Research and Clinical Practice.2022; 41(2): 136.     CrossRef
  • Prevalence of Type 2 Diabetes Mellitus among Korean Children, Adolescents, and Adults Younger than 30 Years: Changes from 2002 to 2016
    Yong Hee Hong, In-Hyuk Chung, Kyungdo Han, Sochung Chung
    Diabetes & Metabolism Journal.2022; 46(2): 297.     CrossRef
  • Synergistic association between underweight and type 2 diabetes on the development of laryngeal cancer: a national population-based retrospective cohort study
    Oh. Hyeong Lee, Yong-Moon Park, Seung-Hyun Ko, Kyuna Lee, Yeonji Kim, Kyungdo Han, Jung-Hae Cho
    BMC Cancer.2022;[Epub]     CrossRef
  • Efficacy of Geumguesingi-hwan (jinkuishenqi-wan, kinkijinki-gan) in decreasing blood glucose levels in patients with uncomplicated type 2 diabetes
    Hyun-Jin Choi, Ji-Soo Baek, Cheon-Hoo Jeon, Seon-Mi Shin, Chung-Sik Cho
    Medicine.2022; 101(12): e29079.     CrossRef
  • Effect of Motivational Interviewing Training on Diabetes Educators’ Counseling Skills and Self-Efficacy
    Sung-Chul Lim
    The Journal of Korean Diabetes.2022; 23(1): 57.     CrossRef
  • Management Status of Patients with Type 2 Diabetes Mellitus at General Hospitals in Korea: A 5-Year Follow-Up Study
    Jin Hee Jung, Jung Hwa Lee, Hyang Mi Jang, Young Na, Hee Sun Choi, Yeon Hee Lee, Yang Gyo Kang, Na Rae Kim, Jeong Rim Lee, Bok Rye Song, Kang Hee Sim
    The Journal of Korean Diabetes.2022; 23(1): 64.     CrossRef
  • Korean naked waxy barley (saechalssal) extract reduces blood glucose in diabetic mice by modulating the PI3K-Akt-GSK3β pathway
    Ju Ri Ham, Young-Jin Son, Yongjin Lee, Hyun-Jin Lee, Jiyoung Yeo, Mi Ja Lee, Mi-Kyung Lee
    Biomedicine & Pharmacotherapy.2022; 150: 112976.     CrossRef
  • Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study
    Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2022; 37(2): 272.     CrossRef
  • Suicide Risk in Patients With Diabetes Varies by the Duration of Diabetes: The Korea National Health and Nutrition Examination Survey (2019)
    Young-Chan Kim, Yoo Hyun Um, Sung-Min Kim, Tae-Won Kim, Ho-Jun Seo, Seung-Chul Hong, Jong-Hyun Jeong
    Psychiatry Investigation.2022; 19(4): 326.     CrossRef
  • Gene‐environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels
    Ji Eun Lim, Ji‐one Kang, Tae‐Woong Ha, Hae‐Un Jung, Dong Jun Kim, Eun Ju Baek, Han Kyul Kim, Ju Yeon Chung, Sang Youl Rhee, Mi Kyung Kim, Yeon‐Jung Kim, Taesung Park, Bermseok Oh
    Genetic Epidemiology.2022; 46(5-6): 285.     CrossRef
  • The predictive value of resting heart rate in identifying undiagnosed diabetes in Korean adults: Korea National Health and Nutrition Examination Survey
    Dong-Hyuk Park, Wonhee Cho, Yong-Ho Lee, Sun Ha Jee, Justin Y. Jeon
    Epidemiology and Health.2022; 44: e2022009.     CrossRef
  • Experiences of Sleep Problems Among Older Korean Immigrants
    Yeonsu Song, Gery W. Ryan, Diane Lee, Haesook Kim, Jennifer L. Martin, B. Josea Kramer, Ron D. Hays, Sarah E. Choi
    Research in Gerontological Nursing.2022; 15(4): 193.     CrossRef
  • Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
    Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sung
    Diabetes & Metabolism Journal.2022; 46(3): 464.     CrossRef
  • Diabetes Fact Sheet in Korea 2021
    Jae Hyun Bae, Kyung-Do Han, Seung-Hyun Ko, Ye Seul Yang, Jong Han Choi, Kyung Mook Choi, Hyuk-Sang Kwon, Kyu Chang Won
    Diabetes & Metabolism Journal.2022; 46(3): 417.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Diabetes & Metabolism Journal.2022; 46(3): 355.     CrossRef
  • Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
    Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim
    Diabetes & Metabolism Journal.2022; 46(3): 402.     CrossRef
  • Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Clinical Hypertension.2022;[Epub]     CrossRef
  • A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study
    Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim
    Diabetes, Obesity and Metabolism.2022; 24(9): 1800.     CrossRef
  • Association of prediabetes with death and diabetic complications in older adults: the pros and cons of active screening for prediabetes
    Giwoong Choi, Hojun Yoon, Hyun Ho Choi, Kyoung Hwa Ha, Dae Jung Kim
    Age and Ageing.2022;[Epub]     CrossRef
  • Recent information on test utilization and intraindividual change in anti-glutamic acid decarboxylase antibody in Korea: a retrospective study
    Rihwa Choi, Wonseo Park, Gayoung Chun, Jiwon Lee, Sang Gon Lee, Eun Hee Lee
    BMJ Open Diabetes Research & Care.2022; 10(3): e002739.     CrossRef
  • Correlation of advanced glycation end products and heme oxygenase-1 in Korean diabetic patients
    Ha-Neul Choi, Da-Hye Koo, Jung-Eun Yim
    Journal of Nutrition and Health.2022; 55(3): 348.     CrossRef
  • The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(7): 1099.     CrossRef
  • Development and implementation of patient-level prediction models of end-stage renal disease for type 2 diabetes patients using fast healthcare interoperability resources
    San Wang, Jieun Han, Se Young Jung, Tae Jung Oh, Sen Yao, Sanghee Lim, Hee Hwang, Ho-Young Lee, Haeun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Optical-fibre characteristics based on Fano resonances and sensor application in blood glucose detection
    Jun Zhu, Jinguo Yin
    Optics Express.2022; 30(15): 26749.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 100.     CrossRef
  • Maintaining Physical Activity Is Associated with Reduced Major Adverse Cardiovascular Events in People Newly Diagnosed with Diabetes
    Duhoe Kim, Jaehun Seo, Kyoung Hwa Ha, Dae Jung Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 187.     CrossRef
  • Prevalence of Diabetic Retinopathy in Undiagnosed Diabetic Patients: A Nationwide Population-Based Study
    Han Na Jang, Min Kyong Moon, Bo Kyung Koo
    Diabetes & Metabolism Journal.2022; 46(4): 620.     CrossRef
  • Reproductive Life Span and Severe Hypoglycemia Risk in Postmenopausal Women with Type 2 Diabetes Mellitus
    Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2022; 46(4): 578.     CrossRef
  • Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus
    Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
    Nutrients.2022; 14(15): 3086.     CrossRef
  • The Association of Pachydrusen Characteristics with Choroidal Thickness and Patient’s Age in Polypoidal Choroidal Vasculopathy versus Central Serous Chorioretinopathy
    Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
    International Journal of Molecular Sciences.2022; 23(15): 8353.     CrossRef
  • Experiences of Using Wearable Continuous Glucose Monitors in Adults With Diabetes: A Qualitative Descriptive Study
    Hee Sun Kang, Hyang Rang Park, Chun-Ja Kim, Savitri Singh-Carlson
    The Science of Diabetes Self-Management and Care.2022; 48(5): 362.     CrossRef
  • Prediction Model for Hypertension and Diabetes Mellitus Using Korean Public Health Examination Data (2002–2017)
    Yong Whi Jeong, Yeojin Jung, Hoyeon Jeong, Ji Hye Huh, Ki-Chul Sung, Jeong-Hun Shin, Hyeon Chang Kim, Jang Young Kim, Dae Ryong Kang
    Diagnostics.2022; 12(8): 1967.     CrossRef
  • Recent Increases in Influenza-Related Hospitalizations, Critical Care Resource Use, and In-Hospital Mortality: A 10-Year Population-Based Study in South Korea
    Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park
    Journal of Clinical Medicine.2022; 11(16): 4911.     CrossRef
  • Clinical and economic impact of changing reimbursement criteria for statin treatment among patients with type 2 diabetes mellitus in South Korea
    Siin Kim, Kyungseon Choi, Ji-yool Kim, Hae Sun Suh
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Experience of Elderly Korean Women with Diabetes and Multimorbidity in Elderly Couple Households: A Qualitative Study
    Oksoo Kim, Hyunju Dan
    Healthcare.2022; 10(9): 1675.     CrossRef
  • Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Sex and Diet-Related Disparities in Low Handgrip Strength among Young and Middle-Aged Koreans: Findings Based on the Korea National Health and Nutrition Examination Survey (KNHANES) from 2014 to 2017
    Inhye Kim, Kumhee Son, Su Jin Jeong, Hyunjung Lim
    Nutrients.2022; 14(18): 3816.     CrossRef
  • Rising Incidence of Diabetes in Young Adults in South Korea: A National Cohort Study
    Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes & Metabolism Journal.2022; 46(5): 803.     CrossRef
  • Analysis of the Association between Metabolic Syndrome and Renal Function in Middle-Aged Patients with Diabetes
    Yoonjin Park, Su Jung Lee
    International Journal of Environmental Research and Public Health.2022; 19(18): 11832.     CrossRef
  • Exploring the risk factors of impaired fasting glucose in middle-aged population living in South Korean communities by using categorical boosting machine
    Haewon Byeon
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Body mass index and stroke risk among patients with diabetes mellitus in Korea
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee, Tariq Jamal Siddiqi
    PLOS ONE.2022; 17(9): e0275393.     CrossRef
  • Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population
    Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang, Giacomo Pucci
    PLOS ONE.2022; 17(10): e0275746.     CrossRef
  • Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes
    Tae Kyung Yoo, Mi Yeon Lee, Sul A. Lee, Eun Sun Cheong, Mi Hae Seo, Ki Chul Sung
    Journal of Clinical Medicine.2022; 11(19): 5933.     CrossRef
  • Risk of Carotid Atherosclerosis in Subjects with Prediabetes Overlapping Metabolic Syndrome
    Seol A Jang, Kyoung Min Kim, Seok Won Park, Chul Sik Kim
    Metabolic Syndrome and Related Disorders.2022; 20(10): 599.     CrossRef
  • Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study
    Jiho Park, Ji Hyun Yoon, Hyun Kyun Ki, Kyungdo Han, Hyungjin Kim
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Analysis of Clinical and Functional Outcomes according to the Blood Sugar Control Status at the Time of Ankle Fractures Resulting from Rotational Injuries
    Jun Young Lee, Dong Seop Lim, Seung Hyun Lee, Seo Jin Park
    Journal of the Korean Fracture Society.2022; 35(4): 135.     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Musculoskeletal complications in patients with diabetes mellitus
    Jong Han Choi, Hae-Rim Kim, Kee-Ho Song
    The Korean Journal of Internal Medicine.2022; 37(6): 1099.     CrossRef
  • Blood Biochemical Characteristics, Dietary Intake, and Risk Factors Related to Poor HbA1c Control in Elderly Korean Diabetes Patients: Comparison between the 4th(2007-2009) and the 7th(2016-2018) Korea National Health and Nutrition Examination Surveys
    Sung-Won Oh, Sook-Bae Kim
    Korean Journal of Community Nutrition.2022; 27(5): 406.     CrossRef
  • Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
    Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(11): 1899.     CrossRef
  • Brachial-ankle pulse wave velocity as a predictor of long-term cardiovascular events in 2174 subjects with type 2 diabetes mellitus: A retrospective cohort study
    Hack-Lyoung Kim, Won Kyeong Jeon, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
    Medicine.2022; 101(45): e31758.     CrossRef
  • Artificial Intelligence-based Prediction of Diabetes and Prediabetes Using Health Checkup Data in Korea
    Hyeonseop Yuk, Juhui Gim, Jung Kee Min, Jaesuk Yun, Tae-Young Heo
    Applied Artificial Intelligence.2022;[Epub]     CrossRef
  • Sex Differences in the Effects of CDKAL1 Variants on Glycemic Control in Diabetic Patients: Findings from the Korean Genome and Epidemiology Study
    Hye Ah Lee, Hyesook Park, Young Sun Hong
    Diabetes & Metabolism Journal.2022; 46(6): 879.     CrossRef
  • Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
    Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon
    Diabetes & Metabolism Journal.2022; 46(6): 819.     CrossRef
  • Classification of Type 2 Diabetes Incidence Risk and the Health Behavior of the 30–50-Year-Old Korean Adults: Latent Class Analysis
    Roma Seol, Jin-Ho Chun
    International Journal of Environmental Research and Public Health.2022; 19(24): 16600.     CrossRef
  • Association between Amount of Alcohol Consumption and Serum Fasting Glucose Level in Korean Male in their 40s and 50s: The Seventh Korea National Health and Nutrition Examination Survey 2016-2018
    Jihyun Kim
    Korean Journal of Family Practice.2022; 12(5): 320.     CrossRef
  • Associated Factors with Health-related Quality of Life among Older Adults with Diabetes in Korea
    Eun-Kyung Lee, Sun-Young Jung
    The Korean Journal of Rehabilitation Nursing.2022; 25(2): 61.     CrossRef
  • Chronic Disease Prediction Using the Common Data Model: Development Study
    Chanjung Lee, Brian Jo, Hyunki Woo, Yoori Im, Rae Woong Park, ChulHyoung Park
    JMIR AI.2022; 1(1): e41030.     CrossRef
  • Threshold Dose-Response Association between Smoking Pack-Years and the Risk of Gallbladder Cancer: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • The risk of stroke according to statin medication compliance in older people with chronic periodontitis: an analysis using the Korea National Health Insurance Service-Senior Cohort Database
    Seon-Rye Kim, Minkook Son, Yu-Rin Kim
    Epidemiology and Health.2022; 44: e2022055.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
    Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
  • Treatment Patterns of Type 2 Diabetes Assessed Using a Common Data Model Based on Electronic Health Records of 2000–2019
    Kyung Ae Lee, Heung Yong Jin, Yu Ji Kim, Yong-Jin Im, Eun-Young Kim, Tae Sun Park
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Factors Associated with Depressive Symptoms in Korean Adults with Diabetes Mellitus: A Cross-Sectional Study
    Mihyun Jeong
    Healthcare.2021; 9(8): 1049.     CrossRef
  • Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
    Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
    The Korean Journal of Internal Medicine.2021; 36(5): 1049.     CrossRef
  • Metabolic Effects of Gastrectomy and Duodenal Bypass in Early Gastric Cancer Patients with T2DM: A Prospective Single-Center Cohort Study
    Young Ki Lee, Eun Kyung Lee, You Jin Lee, Bang Wool Eom, Hong Man Yoon, Young-Il Kim, Soo Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Sun-Young Kong, Min Kyong Yoo, Yul Hwangbo, Young-Woo Kim, Il Ju Choi, Hak Jin Kim, Mi Hyang Kwak, Keun Won Ryu
    Journal of Clinical Medicine.2021; 10(17): 4008.     CrossRef
  • Sex- and Age-Specific Trends in Cardiovascular Health in Korea, 2007–2018
    So Mi Jemma Cho, Hokyou Lee, Hyeon Chang Kim
    Korean Circulation Journal.2021; 51(11): 922.     CrossRef
  • Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: 52-Week Results from a Prospective Observational Study
    Hae Jin Kim, Young Sik Kim, Chang Beom Lee, Moon-Gi Choi, Hyuk-Jae Chang, Soo Kyoung Kim, Jae Myung Yu, Tae Ho Kim, Ji Hyun Lee, Kyu Jeung Ahn, Kyung Wan Min, Eun Jung Kyung, Yeo Kyeong Kim, Kwan Woo Lee
    Diabetes Therapy.2021; 12(11): 2907.     CrossRef
  • RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years
    Dong-Hwa Lee, Eu-Jeong Ku, Tae-Keun Oh, Hyun-Jeong Jeon
    Genes.2021; 12(9): 1445.     CrossRef
  • Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study
    You-Bin Lee, Bongsung Kim, Kyungdo Han, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Journal of Lipid and Atherosclerosis.2021; 10(3): 303.     CrossRef
  • A Century of Progress in Diabetes Care with Insulin: A History of Innovations and Foundation for the Future
    Seung-Hwan Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2021; 45(5): 629.     CrossRef
  • Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
    Young-eun Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
    Diabetes Research and Clinical Practice.2021; 181: 109082.     CrossRef
  • Symptom Clusters and Quality of Life in Patients with Type 2 Diabetes Mellitus
    Su-Yeon Hong, Yang-Sook Yoo
    Korean Journal of Adult Nursing.2021; 33(5): 498.     CrossRef
  • The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort
    Joungyoun Kim, Sang-Jun Shin, Hee-Taik Kang, Claudio Passino
    PLOS ONE.2021; 16(11): e0259212.     CrossRef
  • Effect of Breastfeeding and Its Duration on Impaired Fasting Glucose and Diabetes in Perimenopausal and Postmenopausal Women: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2019
    Byung-Soo Kwan, In-Ae Cho, Ji-Eun Park
    Medicines.2021; 8(11): 71.     CrossRef
  • The Correlation between Carotid Intima-Media Thickness and Neutrophil to Lymphocyte Ratio in Prediabetes Patients
    Dayoung Lee, Mi-Jeong Park, Mee Young Kim, Jung Jin Cho, Jong Lull Yoon
    Korean Journal of Family Medicine.2021; 42(6): 464.     CrossRef
  • Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
    Bo Kyung Koo, Seoil Moon, Min Kyong Moon
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Restoration for the foregut surgery: bridging gaps between foregut surgery practice and academia
    Ye-lim Shin, Shin-Hoo Park, Yeongkeun Kwon, Chang Min Lee, Sungsoo Park
    Journal of Minimally Invasive Surgery.2021; 24(4): 175.     CrossRef
  • Prevalence and Treatment of Diabetes in China, 2013-2018
    Limin Wang, Wen Peng, Zhenping Zhao, Mei Zhang, Zumin Shi, Ziwei Song, Xiao Zhang, Chun Li, Zhengjing Huang, Xiaomin Sun, Linhong Wang, Maigeng Zhou, Jing Wu, Youfa Wang
    JAMA.2021; 326(24): 2498.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2021; 22(4): 244.     CrossRef
  • Spatiotemporal analyses of the epidemiological characteristics of diabetes mellitus
    Sang Youl Rhee
    Epidemiology and Health.2021; 43: e2021102.     CrossRef
  • Associations between grip strength and glycemic control in type 2 diabetes mellitus: an analysis of data from the 2014-2019 Korea National Health and Nutrition Examination Survey
    Harim Choe, Hoyong Sung, Geon Hui Kim, On Lee, Hyo Youl Moon, Yeon Soo Kim
    Epidemiology and Health.2021; 43: e2021080.     CrossRef
Editorial
Early Development of Bidirectional Associations between Sleep Disturbance and Diabetes
Yongin Cho
Diabetes Metab J. 2020;44(5):668-670.   Published online October 21, 2020
DOI: https://doi.org/10.4093/dmj.2020.0198
  • 3,637 View
  • 114 Download
  • 3 Web of Science
  • 5 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
  • Sueño y riesgo cardiometabólico. Revisión narrativa
    J. Ildefonzo Arocha Rodulfo, Gestne Aure Fariñez, Fernando Carrera
    Clínica e Investigación en Arteriosclerosis.2024; 36(1): 38.     CrossRef
  • Sleep and cardiometabolic risk. Narrative revision
    J. Ildefonzo Arocha Rodulfo, Gestne Aure Fariñez, Fernando Carrera
    Clínica e Investigación en Arteriosclerosis (English Edition).2024; 36(1): 38.     CrossRef
  • Sleep problems and their predictors in community-dwelling older adults with diabetes in India: Evidence from the Longitudinal Ageing Study in India
    Vansh Maheshwari, Saurav Basu
    Sleep Medicine: X.2024; 7: 100108.     CrossRef
  • Understanding the relationship between sleep and quality of life in type 2 diabetes: A systematic review of the literature
    Bróna Laverty, Sreelakshmi Puthezhath Jayanandan, Sinéad Smyth
    Journal of Health Psychology.2023; 28(8): 693.     CrossRef
  • Impact of Retirement on Sleep Problems Among Older Workers and Their Partners
    Miriam Mutambudzi, Hanna van Solinge, Suzanne Meeks
    The Gerontologist.2021; 61(8): 1287.     CrossRef
Corrigendum
Corrigenda: Table Correction. Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee
Diabetes Metab J. 2019;43(5):731-731.   Published online October 24, 2019
DOI: https://doi.org/10.4093/dmj.2019.0188
Corrects: Diabetes Metab J 2019;43(1):31
  • 3,343 View
  • 37 Download
PDFPubReader   
Original Article
Clinical Diabetes & Therapeutics
Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors
Ji-Yeon Lee, Yongin Cho, Minyoung Lee, You Jin Kim, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
Diabetes Metab J. 2019;43(2):158-173.   Published online January 25, 2019
DOI: https://doi.org/10.4093/dmj.2018.0057
  • 5,954 View
  • 160 Download
  • 15 Web of Science
  • 15 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We investigated the predictive markers for the therapeutic efficacy and the best combination of sodium-glucose co-transporter 2 (SGLT2) inhibitors (empagliflozin, dapagliflozin, and ipragliflozin) therapy in patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 804 patients with T2DM who had taken SGLT2 inhibitor as monotherapy or an add-on therapy were analyzed. Multivariate regression analyses were performed to identify the predictors of SGLT2 inhibitor response including the classes of baseline anti-diabetic medications.

Results

After adjusting for age, sex, baseline body mass index (BMI), diabetes duration, duration of SGLT2 inhibitor use, initial glycosylated hemoglobin (HbA1c) level, estimated glomerular filtration rate (eGFR), and other anti-diabetic agent usage, multivariate analysis revealed that shorter diabetes duration, higher initial HbA1c and eGFR were associated with better glycemic response. However, baseline BMI was inversely correlated with glycemic status; lean subjects with well-controlled diabetes and obese subjects with inadequately controlled diabetes received more benefit from SGLT2 inhibitor treatment. In addition, dipeptidyl peptidase 4 (DPP4) inhibitor use was related to a greater reduction in HbA1c in patients with higher baseline HbA1c ≥7%. Sulfonylurea users experienced a larger change from baseline HbA1c but the significance was lost after adjustment for covariates and metformin and thiazolidinedione use did not affect the glycemic outcome.

Conclusion

A better response to SGLT2 inhibitors is expected in Korean T2DM patients who have higher baseline HbA1c and eGFR with a shorter diabetes duration. Moreover, the add-on of an SGLT2 inhibitor to a DPP4 inhibitor is likely to show the greatest glycemic response.

Citations

Citations to this article as recorded by  
  • Predictors of efficacy of Sodium‐GLucose Transporter‐2 inhibitors and Glucagon‐Like Peptide 1 receptor agonists: A retrospective cohort study
    Daniele Scoccimarro, Giacomo Cipani, Ilaria Dicembrini, Edoardo Mannucci
    Diabetes/Metabolism Research and Reviews.2024;[Epub]     CrossRef
  • Short-term effectiveness of dapagliflozin versus DPP-4 inhibitors in elderly patients with type 2 diabetes: a multicentre retrospective study
    M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini, Federica Ginestra, Gloria Formoso, Agostino Consoli, Francesco Andreozzi, Giorgio Sesti, Salvatore Turco, Luigi Lucibelli, Adriano Gatti, Raffaella
    Journal of Endocrinological Investigation.2023; 46(7): 1429.     CrossRef
  • Treatment effect heterogeneity following type 2 diabetes treatment with GLP1-receptor agonists and SGLT2-inhibitors: a systematic review
    Katherine G. Young, Eram Haider McInnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. McGovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, John M. Dennis, Deirdre K. Tobi
    Communications Medicine.2023;[Epub]     CrossRef
  • Predictors of HbA1c treatment response to add-on medication following metformin monotherapy: a population-based cohort study
    Wei Ying Tan, Wynne Hsu, Mong Li Lee, Ngiap Chuan Tan
    Scientific Reports.2023;[Epub]     CrossRef
  • Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extensio
    Jun Sung Moon, Il Rae Park, Hae Jin Kim, Choon Hee Chung, Kyu Chang Won, Kyung Ah Han, Cheol-Young Park, Jong Chul Won, Dong Jun Kim, Gwan Pyo Koh, Eun Sook Kim, Jae Myung Yu, Eun-Gyoung Hong, Chang Beom Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2023; 47(6): 808.     CrossRef
  • Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study
    Seung-Hwan Lee, Kyung-Wan Min, Byung-Wan Lee, In-Kyung Jeong, Soon-Jib Yoo, Hyuk-Sang Kwon, Yoon-Hee Choi, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2021; 45(3): 339.     CrossRef
  • Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice
    Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan
    Clinical Science.2021; 135(7): 943.     CrossRef
  • Sodium-Glucose Cotransporter-2 Inhibitor for Renal Function Preservation in Patients with Type 2 Diabetes Mellitus: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement
    Tae Jung Oh, Ju-Young Moon, Kyu Yeon Hur, Seung Hyun Ko, Hyun Jung Kim, Taehee Kim, Dong Won Lee, Min Kyong Moon
    Diabetes & Metabolism Journal.2020; 44(4): 489.     CrossRef
  • Differential indication for SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with established atherosclerotic heart disease or at risk for congestive heart failure
    Francesco Giorgino, Irene Caruso, Julia Moellmann, Michael Lehrke
    Metabolism.2020; 104: 154045.     CrossRef
  • Clinical Predictors of the Hypoglycemic Effect of Sodium–Glucose Co-transporter-2 Inhibitors in Hyperuricemic Patients: A Retrospective Descriptive Observational Study
    Toshinori Hirai, Yuya Kawagoe, Motoki Kei, Ryuichi Ogawa, Toshimasa Itoh
    Biological and Pharmaceutical Bulletin.2020; 43(5): 782.     CrossRef
  • Sodium-glucose cotransporter-2 inhibitor for renal function preservation in patients with type 2 diabetes mellitus: A Korean Diabetes Association and Korean Society of Nephrology consensus statement
    Tae Jung Oh, Ju-Young Moon, Kyu Yeon Hur, Seung Hyun Ko, Hyun Jung Kim, Taehee Kim, Dong Won Lee, Min Kyong Moon
    Kidney Research and Clinical Practice.2020; 39(3): 269.     CrossRef
  • Efficacy of Once-Weekly Semaglutide vs Empagliflozin Added to Metformin in Type 2 Diabetes: Patient-Level Meta-analysis
    Ildiko Lingvay, Matthew S Capehorn, Andrei-Mircea Catarig, Pierre Johansen, Jack Lawson, Anna Sandberg, Robert Shaw, Abby Paine
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(12): e4593.     CrossRef
  • Letter: Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors (Diabetes Metab J 2019;43:158–73)
    Kyung-Soo Kim
    Diabetes & Metabolism Journal.2019; 43(3): 377.     CrossRef
  • Response: Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors (Diabetes Metab J 2019;43:158–73)
    Ji-Yeon Lee, Eun Seok Kang
    Diabetes & Metabolism Journal.2019; 43(3): 379.     CrossRef
  • An Age of Sodium-Glucose Cotransporter-2 Inhibitor Priority: Are We Ready?
    Ji A Seo
    Diabetes & Metabolism Journal.2019; 43(5): 578.     CrossRef
Review
Complications
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee
Diabetes Metab J. 2019;43(1):31-45.   Published online December 17, 2018
DOI: https://doi.org/10.4093/dmj.2019.0011
Correction in: Diabetes Metab J 2019;43(5):731
  • 8,237 View
  • 167 Download
  • 106 Web of Science
  • 101 Crossref
AbstractAbstract PDFPubReader   

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.

Citations

Citations to this article as recorded by  
  • Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study
    Eugene Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Yong-ho Lee, Seung Up Kim
    Metabolism.2024; 152: 155789.     CrossRef
  • Intact ketogenesis predicted reduced risk of moderate-severe metabolic-associated fatty liver disease assessed by liver transient elastography in newly diagnosed type 2 diabetes
    Sejeong Lee, Jaehyun Bae, Seung Up Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • ZJU Index as a Predictive Tool for Diabetes Incidence: Insights from a Population-Based Cohort Study
    Chenjiao Wu, Yi Hao Loh, Hangkai Huang, Chengfu Xu
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 715.     CrossRef
  • Sigmoidal relationship between liver fat content and nonalcoholic fatty liver disease in Chinese adults
    Pingping Yu, Huachao Yang, Hu Li, Ying Mei, Yuanyuan Wu, Hongfeng Cheng, Huiru Su, Yueling Deng, Tao Jiang, Zhongxiang He, Peng Hu
    Postgraduate Medical Journal.2024;[Epub]     CrossRef
  • Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study
    Stephen A. Harrison, Juan P. Frias, K. Jean Lucas, Gary Reiss, Guy Neff, Sureka Bollepalli, Yan Su, Doreen Chan, Erik J. Tillman, Ali Moulton, Brittany de Temple, Arian Zari, Reshma Shringarpure, Timothy Rolph, Andrew Cheng, Kitty Yale
    Clinical Gastroenterology and Hepatology.2024;[Epub]     CrossRef
  • Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography
    Gyuri Kim, Tae Yang Yu, Jae Hwan Jee, Ji Cheol Bae, Mira Kang, Jae Hyeon Kim
    Diabetes & Metabolism.2024; 50(3): 101534.     CrossRef
  • Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
    Maha Hussein, Aasem Saif, Mona Amin, Osama Khalafallah, Ahmed Hussien, Samar Aboulsoud, Shrook Mousa, S. Razzaque Mohammed
    Journal of Nutrition and Metabolism.2023; 2023: 1.     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • Liver fat content assessed by conventional B-mode ultrasound and metabolic profile in non-diabetic patients: Implications for clinical practice
    Rosanna Villani, Grazia Pia Magnati, Giulia Tuccari, Moris Sangineto, Antonino Davide Romano, Tommaso Cassano, Gaetano Serviddio
    Ultrasound.2023; 31(3): 177.     CrossRef
  • Association of cardiovascular health metrics with annual incidence of prediabetes or diabetes: Analysis of a nationwide real‐world database
    Akira Okada, Hidehiro Kaneko, Satoshi Matsuoka, Hidetaka Itoh, Yuta Suzuki, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Satoko Yamaguchi, Koichi Node, Toshimasa Yamauchi, Hideo Yasunaga, Issei Komuro
    Journal of Diabetes Investigation.2023; 14(3): 452.     CrossRef
  • Effects of Environmental Cadmium Exposure on the Liver in Korean Adults: Cross-Sectional and Longitudinal Studies
    Mi-Na Seo, Sang-Yong Eom, Ji-Ae Lim, Jung-Eum Lee, Byung-Sun Choi, Ho-Jang Kwon, Young-Seoub Hong, Heon Kim, Jung-Duck Park
    Archives of Environmental Contamination and Toxicology.2023; 84(2): 237.     CrossRef
  • Newer Glucose-Lowering Therapies in Older Adults with Type 2 Diabetes
    Anika Bilal, Richard E. Pratley
    Endocrinology and Metabolism Clinics of North America.2023; 52(2): 355.     CrossRef
  • CD24 Gene Expression as a Risk Factor for Non-Alcoholic Fatty Liver Disease
    Mona A. Amin, Halla M. Ragab, Nabila Abd El Maksoud, Wafaa Abd Elaziz
    Diagnostics.2023; 13(5): 984.     CrossRef
  • Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes & Metabolism Journal.2023; 47(2): 220.     CrossRef
  • Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression Risk in Patients with Type 2 Diabetes Mellitus
    Yongin Cho, Hye-Sun Park, Byung Wook Huh, Yong-ho Lee, Seong Ha Seo, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, So Hun Kim
    Diabetes & Metabolism Journal.2023; 47(2): 232.     CrossRef
  • Nonalcoholic fatty liver disease and type 2 diabetes: an observational and Mendelian randomization study
    Yuetian Yu, Yuefeng Yu, Yuying Wang, Yi Chen, Ningjian Wang, Bin Wang, Yingli Lu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
    Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail, Mostafa A. Farrag
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • Fatty Liver & Diabetes Statistics in Korea: Nationwide Data 2009 to 2017
    Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park
    Diabetes & Metabolism Journal.2023; 47(3): 347.     CrossRef
  • Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis
    Hye Jin Chun, Eun Ran Kim, Minyoung Lee, Da Hyun Choi, Soo Hyun Kim, Eugene Shin, Jin-Hong Kim, Jin Won Cho, Dai Hoon Han, Bong-Soo Cha, Yong-ho Lee
    Metabolism.2023; 145: 155612.     CrossRef
  • Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value
    Yu-Qi Li, Lei Xin, Yu-Chi Zhao, Shang-Qi Li, Ya-Nuo Li
    World Journal of Hepatology.2023; 15(6): 786.     CrossRef
  • Increased risk of incident diabetes in patients with MAFLD not meeting the criteria for NAFLD
    So Hee Park, Jiyun Park, So Yoon Kwon, You-Bin Lee, Gyuri Kim, Kyu Yeon Hur, Janghyun Koh, Jae Hwan Jee, Jae Hyeon Kim, Mira Kang, Sang-Man Jin
    Scientific Reports.2023;[Epub]     CrossRef
  • Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease
    Jaehyun Bae, Byung-Wan Lee
    Biomedicines.2023; 11(7): 1928.     CrossRef
  • An Evidence-Based Review of Diabetes Care: History, Types, Relationship to Cancer and Heart Disease, Co-Morbid Factors, and Preventive Measures
    Umesh Chandra Gupta, Subhas Chandra Gupta, Shayle Sugandh Gupta
    Current Nutrition & Food Science.2023; 19(4): 399.     CrossRef
  • Associations of serum aminotransferase and the risk of all-cause and cause-specific mortality in Chinese type 2 diabetes: a community-based cohort study
    Jian Su, Haoyu Guan, Xikang Fan, Hao Yu, Yu Qin, Jie Yang, Zheng Zhu, Chong Shen, Enchun Pan, Yan Lu, Jin-Yi Zhou, Ming Wu
    BMJ Open.2023; 13(7): e068160.     CrossRef
  • Retinoic acid signaling in fatty liver disease
    Fathima N. Cassim Bawa, Yanqiao Zhang
    Liver Research.2023; 7(3): 189.     CrossRef
  • Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy
    Reeju Amatya, Donghee Lee, Kyoung Ah Min, Meong Cheol Shin
    Pharmaceutics.2023; 15(7): 1963.     CrossRef
  • Prevalence of Non-Alcoholic Fatty Liver Disease and Its Risk Factors in Korean Population
    Sang Gyeong Lee, Songchan Oh, Moon Seong Kim, Jooyeon Kim, Eunjin Jung, Young Jun Kim, Jiyoun Hong
    Food Supplements and Biomaterials for Health.2023;[Epub]     CrossRef
  • Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis
    Hongqiong Fan, Shanshan Liu, Benzheng Jiao, Xinyue Liang
    Molecular Medicine Reports.2023;[Epub]     CrossRef
  • CT-based measurement of visceral adipose tissue volume as a reliable tool for assessing metabolic risk factors in prediabetes across subtypes
    Jihyun Kim, Keunyoung Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • The Role of the Fatty Liver Index (FLI) in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review
    Teodora Biciusca, Sorina Ionelia Stan, Mara Amalia Balteanu, Ramona Cioboata, Alice Elena Ghenea, Suzana Danoiu, Ana-Maria Bumbea, Viorel Biciusca
    Diagnostics.2023; 13(21): 3316.     CrossRef
  • Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease
    Min Li, Ai Zeng, Xinle Tang, Hui Xu, Wei Xiong, Yanying Guo
    Scientific Reports.2023;[Epub]     CrossRef
  • Prevalence of High and Moderate Risk of Liver Fibrosis Among Patients With Diabetes at a Noncommunicable Diseases (NCD) Clinic in a Primary Healthcare Center in Northern India
    Anubhav Mondal, Aninda Debnath, Ghurumourthy Dhandapani, Abhishek Sharma, Shveta Lukhmana, Geeta Yadav
    Cureus.2023;[Epub]     CrossRef
  • Therapeutic outcome of dapagliflozin on various parameters in non-alcoholic fatty liver disease (NAFLD) patients
    Mazhar Hussain, Muhammad Zafar Majeed Babar, Saba Tariq, Muhammad Irfan Ahmad, Lubna Akhtar
    International Journal of Diabetes in Developing Countries.2022; 42(2): 290.     CrossRef
  • Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
    Environmental Research.2022; 204: 111888.     CrossRef
  • Association of Prenatal Famine Exposure With Inflammatory Markers and Its Impact on Adulthood Liver Function Across Consecutive Generations
    Shiwei Yan, Jingqi Ruan, Yu Wang, Jiaxu Xu, Changhao Sun, Yucun Niu
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Serum Metabolomics in Patients with Coexisting NAFLD and T2DM Using Liquid Chromatography-Mass Spectrometry
    Cheng Hu, Xiaoyu Zhuang, Jiaqi Zhang, Tao Wang, Shengnan Du, Jinping Wang, Xuelian Peng, Qin Cao, Mingcai Zhang, Yuanye Jiang
    Laboratory Medicine.2022; 53(4): 360.     CrossRef
  • Genistein—Opportunities Related to an Interesting Molecule of Natural Origin
    Ewa Garbiec, Judyta Cielecka-Piontek, Magdalena Kowalówka, Magdalena Hołubiec, Przemysław Zalewski
    Molecules.2022; 27(3): 815.     CrossRef
  • Renal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus
    Hae Kyung Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Diabetes & Metabolism Journal.2022; 46(1): 104.     CrossRef
  • Long-term effects of the changes in hepatic steatosis status on the risk of incident type 2 diabetes mellitus: A 15-year community-based prospective cohort study
    Seung Min Chung, Min Kyu Kang, Jinho Jung, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee, Rohit Loomba, Jung Gil Park, Jun Sung Moon
    Diabetes Research and Clinical Practice.2022; 184: 109208.     CrossRef
  • Prevalence and Risk Factors of Advanced Liver Fibrosis in a Population‐Based Study in Germany
    Yvonne Huber, Andreas Schulz, Irene Schmidtmann, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Peter R. Galle, Philipp S. Wild, Karl J. Lackner, Jörn M. Schattenberg
    Hepatology Communications.2022; 6(6): 1457.     CrossRef
  • Non-alcoholic fatty liver disease: Epidemiology, pathophysiology and an update on the therapeutic approaches
    RehabF Abdel-Rahman
    Asian Pacific Journal of Tropical Biomedicine.2022; 12(3): 99.     CrossRef
  • State-of-the-Art Overview of the Pharmacological Treatment of Non-Alcoholic Steatohepatitis
    Yongin Cho, Yong-ho Lee
    Endocrinology and Metabolism.2022; 37(1): 38.     CrossRef
  • Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease
    Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Bong-Soo Cha, Byung-Wan Lee
    Hepatobiliary & Pancreatic Diseases International.2022; 21(3): 241.     CrossRef
  • The associations of hepatic steatosis and fibrosis using fatty liver index and BARD score with cardiovascular outcomes and mortality in patients with new-onset type 2 diabetes: a nationwide cohort study
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients
    Muhammad Adnan, Abdul Wajid, Wasif Noor, Andleeb Batool, Muhammad Aasim, Kamran Abbas, Quratul Ain
    Journal of Genetic Engineering and Biotechnology.2022; 20(1): 68.     CrossRef
  • Concordance between indirect fibrosis and steatosis indices and their predictors in subjects with overweight/obesity
    Gaggini Melania, Vigna Luisella, Di Piazza Salvina, Gori Francesca, Tirelli Amedea Silvia, Bamonti Fabrizia, Maltinti Maristella, Napolitano Filomena, Chatzianagnostou Kyriazoula, Cristina Vassalle
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2022; 27(7): 2617.     CrossRef
  • Stéatopathie métabolique hépatique évaluée par le FibroScan® avec contrôle des paramètres d’atténuation (CAP) chez la personne diabétique de type 2 en Côte d’Ivoire
    Jacko Abodo, Dimitri Kouamé, Jocelyne Danho, Moumouni Léilatou, Pierre Koffi-Dago, Adelaïde Hué, Assita Yao, Franck Kouassi, Anselme N’Guessan, Fulgence Bathaix
    Médecine des Maladies Métaboliques.2022; 16(6): 550.     CrossRef
  • Non-invasive diagnosis and staging of non-alcoholic fatty liver disease
    Stergios Kechagias, Mattias Ekstedt, Christian Simonsson, Patrik Nasr
    Hormones.2022; 21(3): 349.     CrossRef
  • Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004
    Hyunji Sang, Kyu-Na Lee, Chang Hee Jung, Kyungdo Han, Eun Hee Koh
    Scientific Reports.2022;[Epub]     CrossRef
  • Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans
    Dae-Jeong Koo, Mi Yeon Lee, Inha Jung, Sun Joon Moon, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Won-Young Lee, Ki Won Oh, Se Eun Park
    Journal of Personalized Medicine.2022; 12(7): 1142.     CrossRef
  • Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Da Hea Seo, Young Ju Suh, Yongin Cho, Seong Hee Ahn, Seongha Seo, Seongbin Hong, Yong-ho Lee, Young Ju Choi, Eunjig Lee, So Hun Kim
    Diabetes & Metabolism Journal.2022; 46(4): 630.     CrossRef
  • New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis
    Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Bogdan-Mircea Mihai
    Life.2022; 12(8): 1189.     CrossRef
  • Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trial
    Jinghan Xu, Chunli Piao, Yue Qu, Tianjiao Liu, Yuting Peng, Qi Li, Xiaohua Zhao, Pei Li, Xuemin Wu, Yawen Fan, Binqin Chen, Jie Yang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Ultrasound-Based Hepatic Elastography in Non-Alcoholic Fatty Liver Disease: Focus on Patients with Type 2 Diabetes
    Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Bogdan-Mircea Mihai
    Biomedicines.2022; 10(10): 2375.     CrossRef
  • Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats
    Yujie Zhong, Zhiman Li, Ruyi Jin, Yanpeng Yao, Silan He, Min Lei, Xin Wang, Chao Shi, Li Gao, Xiaoli Peng
    Nutrients.2022; 14(23): 4994.     CrossRef
  • The associations between changes in hepatic steatosis and heart failure and mortality: a nationwide cohort study
    Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Recent advances and potentiality of postbiotics in the food industry: Composition, inactivation methods, current applications in metabolic syndrome, and future trends
    Yujie Zhong, Tao Wang, Ruilin Luo, Jiayu Liu, Ruyi Jin, Xiaoli Peng
    Critical Reviews in Food Science and Nutrition.2022; : 1.     CrossRef
  • Association of nonalcoholic fatty liver disease with coronary artery disease in type 2 diabetes mellitus: A cross-sectional study from a tertiary care medical college hospital
    Neelakandan Ramya, Golepu Karthikeya, SethuPrabhu Shankar
    Acta Medica International.2022; 9(1): 31.     CrossRef
  • NAFLDin type 2 diabetes mellitus: Still many challenging questions
    Simona Cernea, Itamar Raz
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • The protective effect of shrimp cooked in different methods on high-cholesterol- induced fatty liver in rats
    Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. AlTamimi, Lujain A. AlMousa, Nora M. AlKehayez, Dalal H. Aljabryn, Reham I. Alagal, Mohammed A. Yahya
    Saudi Journal of Biological Sciences.2021; 28(1): 170.     CrossRef
  • Evolution of liver fibrosis and steatosis markers in patients with type 2 diabetes after metformin treatment for 2 years
    Hye Won Lee, Jae Seung Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
    Journal of Diabetes and its Complications.2021; 35(1): 107747.     CrossRef
  • Prognostic value of non-alcoholic fatty liver disease for predicting cardiovascular events in patients with diabetes mellitus with suspected coronary artery disease: a prospective cohort study
    Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Hironobu Toda, Kentaro Ejiri, Masatoki Yoshida, Yusuke Nanba, Masashi Yoshida, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Implications of Abdominal Adipose Tissue Distribution on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: A Chinese General Population Study
    Chileka Chiyanika, Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Steve C. N. Hui, David K. W. Yeung, Winnie C. W. Chu
    Clinical and Translational Gastroenterology.2021; 12(2): e00300.     CrossRef
  • Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: Diagnosis and Treatment
    Sook Jung Lee, Byung-Wan Lee
    The Journal of Korean Diabetes.2021; 22(1): 38.     CrossRef
  • Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-Analysis
    Jingxuan Lian, Jianfang Fu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Diabetic Kidney Disease, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease: A New Triumvirate?
    Carolina M. Perdomo, Nuria Garcia-Fernandez, Javier Escalada
    Journal of Clinical Medicine.2021; 10(9): 2040.     CrossRef
  • Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy
    Jin Yoo, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang
    Metabolism.2021; 120: 154798.     CrossRef
  • Association Between Thyroid Hormone Levels and Advanced Liver Fibrosis in Patients with Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease
    Jing Du, Sanbao Chai, Xin Zhao, Jianbin Sun, Xiaomei Zhang, Lili Huo
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2399.     CrossRef
  • Association between toothbrushing and non-alcoholic fatty liver disease
    Ji-Youn Kim, Yong-Moon Park, Gyu-Na Lee, Hyun Chul Song, Yu-Bae Ahn, Kyungdo Han, Seung-Hyun Ko, Houkai Li
    PLOS ONE.2021; 16(5): e0243686.     CrossRef
  • Non‐alcoholic fatty liver disease and sarcopenia additively increase mortality: a Korean nationwide survey
    Joon Ho Moon, Bo Kyung Koo, Won Kim
    Journal of Cachexia, Sarcopenia and Muscle.2021; 12(4): 964.     CrossRef
  • Sodium-Glucose Cotransporter-2 Inhibitors Ameliorate Liver Enzyme Abnormalities in Korean Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Won Euh, Soo Lim, Jin-Wook Kim
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Modulation and bioinformatics screening of hepatic mRNA-lncRNAs (HML) network associated with insulin resistance in prediabetic and exercised mice
    Fatemeh Kazeminasab, Sayed Mohammad Marandi, Maryam Baharlooie, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi
    Nutrition & Metabolism.2021;[Epub]     CrossRef
  • Liver Fibrosis Indices for the Prediction of Mortality in Korean Subjects: A 16-Year Prospective Cohort Study
    Tae Jung Oh, Kyuho Kim, Jae Hoon Moon, Sung Hee Choi, Nam H Cho, Hak Chul Jang
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
    Jiwon Kim, Minyoung Lee, Soo Yeon Kim, Ji-Hye Kim, Ji Sun Nam, Sung Wan Chun, Se Eun Park, Kwang Joon Kim, Yong-ho Lee, Joo Young Nam, Eun Seok Kang
    Endocrinology and Metabolism.2021; 36(4): 823.     CrossRef
  • The association of hepatic steatosis and fibrosis with heart failure and mortality
    Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Magnetic Resonance-Based Assessments Better Capture Pathophysiologic Profiles and Progression in Nonalcoholic Fatty Liver Disease
    Seung Joon Choi, Seong Min Kim, Yun Soo Kim, Oh Sang Kwon, Seung Kak Shin, Kyoung Kon Kim, Kiyoung Lee, Ie Byung Park, Cheol Soo Choi, Dong Hae Chung, Jaehun Jung, MunYoung Paek, Dae Ho Lee
    Diabetes & Metabolism Journal.2021; 45(5): 739.     CrossRef
  • Albuminuria Is Associated with Steatosis Burden in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Eugene Han, Mi Kyung Kim, Byoung Kuk Jang, Hye Soon Kim
    Diabetes & Metabolism Journal.2021; 45(5): 698.     CrossRef
  • The potential pathophysiological role of altered lipid metabolism and electronegative low-density lipoprotein (LDL) in non-alcoholic fatty liver disease and cardiovascular diseases
    Hüseyin Vural, Ferah Armutcu, Omer Akyol, Ralf Weiskirchen
    Clinica Chimica Acta.2021; 523: 374.     CrossRef
  • Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
    Kyuhoon Bang, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang
    Diabetes & Metabolism Journal.2021; 45(6): 890.     CrossRef
  • Efficacy and Safety of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
    Yuan Zhu, Jiao Xu, Dong Zhang, Xingyu Mu, Yi Shi, Shangtao Chen, Zengxiang Wu, Shuangqing Li
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects
    Hwi Seung Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    Journal of Clinical Medicine.2021; 11(1): 41.     CrossRef
  • The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
    Jung-Min Lee, Yong-Moon Park, Jae-Seung Yun, Yu-Bae Ahn, Kang-Moon Lee, Dae Bum Kim, Ji Min Lee, Kyungdo Han, Seung-Hyun Ko, Ming-Lung Yu
    PLOS ONE.2020; 15(1): e0226351.     CrossRef
  • Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study
    Hyeok-Hee Lee, Yongin Cho, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Seok Won Park, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis
    Chan-Hee Jung, Eun-Jung Rhee, Hyemi Kwon, Yoosoo Chang, Seungho Ryu, Won-Young Lee
    Endocrinology and Metabolism.2020; 35(1): 165.     CrossRef
  • Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
    Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim, Ji Hye Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Non-invasive diagnosis of nonalcoholic fatty liver disease: impact of age and other risk factors
    Muharrem Bayrak
    The Aging Male.2020; 23(5): 1275.     CrossRef
  • Establishment of a Risk Prediction Model for Non-alcoholic Fatty Liver Disease in Type 2 Diabetes
    Yali Zhang, Rong Shi, Liang Yu, Liping Ji, Min Li, Fan Hu
    Diabetes Therapy.2020; 11(9): 2057.     CrossRef
  • Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease
    Dae Ho Lee
    Endocrinology and Metabolism.2020; 35(2): 243.     CrossRef
  • Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
    Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee
    Diabetes & Metabolism Journal.2020; 44(3): 382.     CrossRef
  • Sarcopenia is associated with non-alcoholic fatty liver disease in men with type 2 diabetes
    D.H. Seo, Y.-h. Lee, S.W. Park, Y.J. Choi, B.W. Huh, E. Lee, K.B. Huh, S.H. Kim, B.-S. Cha
    Diabetes & Metabolism.2020; 46(5): 362.     CrossRef
  • Pharmacological Strategies for Insulin Sensitivity in Obesity and Cancer: Thiazolidinediones and Metformin
    Luana A. Biondo, Alexandre A. S. Teixeira, Karen C. de O. S. Ferreira, Jose C. R. Neto
    Current Pharmaceutical Design.2020; 26(9): 932.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • Toll-like receptor 9, a possible blocker of non-alcoholic steatohepatitis?
    Soung Won Jeong
    Clinical and Molecular Hepatology.2020; 26(2): 185.     CrossRef
  • The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Trace Elements in Medicine and Biology.2020; 62: 126601.     CrossRef
  • Hepatic fibrosis is associated with total proteinuria in Korean patients with type 2 diabetes
    Eugene Han, Yongin Cho, Kyung-won Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-wan Lee
    Medicine.2020; 99(33): e21038.     CrossRef
  • Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping
    Zhipeng Liu, Yang Zhang, Sarah Graham, Xiaokun Wang, Defeng Cai, Menghao Huang, Roger Pique-Regi, Xiaocheng Charlie Dong, Y. Eugene Chen, Cristen Willer, Wanqing Liu
    Journal of Hepatology.2020; 73(2): 263.     CrossRef
  • Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in Patients With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
    Marieke de Vries, Jan Westerink, Karin H A H Kaasjager, Harold W de Valk
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(12): 3842.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
    Eun-Jung Rhee
    Endocrinology and Metabolism.2019; 34(3): 226.     CrossRef
  • Role of sodium-glucose co-transporter-2 inhibitors in the management of nonalcoholic fatty liver disease
    Anastasia Kontana, Konstantinos Tziomalos
    World Journal of Gastroenterology.2019; 25(28): 3664.     CrossRef
Original Articles
Clinical Diabetes & Therapeutics
Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis
Ji-Eun Jang, Yongin Cho, Byung Wan Lee, Ein-Soon Shin, Sun Hee Lee
Diabetes Metab J. 2019;43(3):302-318.   Published online November 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.0062
  • 5,318 View
  • 97 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

This study aimed to assess the effectiveness of exercise intervention in reducing body weight and glycosylated hemoglobin (HbA1c) level in patients with type 2 diabetes mellitus (T2DM) in Korea.

Methods

Cochrane, PubMed, Embase, KoreaMed, KMbase, NDSL, KCI, RISS, and DBpia databases were used to search randomized controlled trials and controlled clinical trials that compared exercise with non-exercise intervention among patients with non-insulin-treated T2DM in Korea. The effectiveness of exercise intervention was estimated by the mean difference in body weight changes and HbA1c level. Weighted mean difference (WMD) with its corresponding 95% confidence interval (CI) was used as the effect size. The pooled mean differences of outcomes were calculated using a random-effects model.

Results

We identified 7,692 studies through literature search and selected 23 articles (723 participants). Compared with the control group, exercise intervention (17 studies) was associated with a significant decline in HbA1c level (WMD, −0.58%; 95% CI, −0.89 to −0.27; I2=73%). Although no significant effectiveness on body weight was observed, eight aerobic training studies showed a significant reduction in body weight (WMD, −2.25 kg; 95% CI, −4.36 to −0.13; I2=17%) in the subgroup analysis.

Conclusion

Exercise significantly improves glycemic control; however, it does not significantly reduce body weight. Aerobic training can be beneficial for patients with non-insulin-treated T2DM in Korea.

Citations

Citations to this article as recorded by  
  • The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis
    Georgia Papagianni, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Constantinos Antonopoulos, Dimitrios Tachmatzidis, Triantafyllos Didangelos, Vaia Lambadiari, Nikolaos P.E. Kadoglou
    Cytokine.2023; 164: 156157.     CrossRef
  • Glucose Control in Korean Patients with Type 2 Diabetes Mellitus according to Body Mass Index
    Ye-lim Shin, Heesoh Yoo, Joo Young Hong, Jooeun Kim, Kyung-do Han, Kyu-Na Lee, Yang-Hyun Kim
    Journal of Obesity & Metabolic Syndrome.2023; 32(1): 55.     CrossRef
  • Exercise therapy for diabetes mellitus
    Chaiho Jeong, Tae-Seo Sohn
    Journal of the Korean Medical Association.2023; 66(7): 427.     CrossRef
  • Effects of an evidence‐based nursing intervention on prevention of anxiety and depression in the postpartum period
    Jun Meng, Junying Du, Xiaoli Diao, Yingxia Zou
    Stress and Health.2022; 38(3): 435.     CrossRef
  • Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
    Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
    International Journal of Obesity.2021; 45(5): 982.     CrossRef
  • Development and validation of the type 2 diabetes mellitus 10-year risk score prediction models from survey data
    Gregor Stiglic, Fei Wang, Aziz Sheikh, Leona Cilar
    Primary Care Diabetes.2021; 15(4): 699.     CrossRef
  • Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-Analysis
    Jingxuan Lian, Jianfang Fu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Exercise Training: The Holistic Approach in Cardiovascular Prevention
    Francesco Giallauria, Teresa Strisciuglio, Gianluigi Cuomo, Anna Di Lorenzo, Andrea D’Angelo, Mario Volpicelli, Raffaele Izzo, Maria Virginia Manzi, Emanuele Barbato, Carmine Morisco
    High Blood Pressure & Cardiovascular Prevention.2021; 28(6): 561.     CrossRef
  • Effect of chronic High Intensity Interval Training on glycosylated haemoglobin in people with type 2 diabetes: a meta-analysis
    María Cristina Arrieta-Leandro, Jessenia Hernández-Elizondo, Judith Jiménez-Díaz
    Human Movement.2021; 24(1): 32.     CrossRef
  • Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
    Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee
    Diabetes & Metabolism Journal.2020; 44(3): 382.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • Factors Influencing Glycemic Control among Type 2 Diabetes Mellitus Patients: The Sixth Korea National Health and Nutrition Examination Survey (2013~2015)
    Mee Ock Gu
    Korean Journal of Adult Nursing.2019; 31(3): 235.     CrossRef
The Effect of DPP-4 Inhibitors on Metabolic Parameters in Patients with Type 2 Diabetes
Eun Yeong Choe, Yongin Cho, Younjeong Choi, Yujung Yun, Hye Jin Wang, Obin Kwon, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang
Diabetes Metab J. 2014;38(3):211-219.   Published online June 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.3.211
  • 4,687 View
  • 70 Download
  • 27 Web of Science
  • 25 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We evaluated the effects of two dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and vildagliptin, on metabolic parameters in patients with type 2 diabetes mellitus.

Methods

A total of 170 type 2 diabetes patients treated with sitagliptin or vildagliptin for more than 24 weeks were selected. The patients were separated into two groups, sitagliptin (100 mg once daily, n=93) and vildagliptin (50 mg twice daily, n=77). We compared the effect of each DPP-4 inhibitor on metabolic parameters, including the fasting plasma glucose (FPG), postprandial glucose (PPG), glycated hemoglobin (HbA1c), and glycated albumin (GA) levels, and lipid parameters at baseline and after 24 weeks of treatment.

Results

The HbA1c, FPG, and GA levels were similar between the two groups at baseline, but the sitagliptin group displayed a higher PPG level (P=0.03). After 24 weeks of treatment, all of the glucose-related parameters were significantly decreased in both groups (P=0.001). The levels of total cholesterol and triglycerides were only reduced in the vildagliptin group (P=0.001), although the sitagliptin group received a larger quantity of statins than the vildagliptin group (P=0.002).The mean change in the glucose- and lipid-related parameters after 24 weeks of treatment were not significantly different between the two groups (P=not significant). Neither sitagliptin nor vildagliptin treatment was associated with a reduction in the high sensitive C-reactive protein level (P=0.714).

Conclusion

Vildagliptin and sitagliptin exert a similar effect on metabolic parameters, but vildagliptin exerts a more potent beneficial effect on lipid parameters.

Citations

Citations to this article as recorded by  
  • Insulin Tregopil: An Ultra-Fast Oral Recombinant Human Insulin Analog: Preclinical and Clinical Development in Diabetes Mellitus
    Shashank Joshi, Vathsala Jayanth, Subramanian Loganathan, Vasan K. Sambandamurthy, Sandeep N. Athalye
    Drugs.2023; 83(13): 1161.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
    Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Ki
    Diabetes & Metabolism Journal.2021; 45(5): 675.     CrossRef
  • Vasculoprotective Effects of Vildagliptin. Focus on Atherogenesis
    Michał Wiciński, Karol Górski, Eryk Wódkiewicz, Maciej Walczak, Magdalena Nowaczewska, Bartosz Malinowski
    International Journal of Molecular Sciences.2020; 21(7): 2275.     CrossRef
  • Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era?
    Niki Katsiki, Ele Ferrannini
    Journal of Diabetes and its Complications.2020; 34(12): 107723.     CrossRef

  • Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus


    Eugene Han, Minyoung Lee, Yong-ho Lee, Hye Soon Kim, Byung-wan Lee, Bong-Soo Cha, Eun Seok Kang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4113.     CrossRef
  • Combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined Alzheimer’s disease and type 2 diabetes
    Samar S. Khalaf, Mohamed M. Hafez, Eman T. Mehanna, Noha M. Mesbah, Dina M. Abo-Elmatty
    Naunyn-Schmiedeberg's Archives of Pharmacology.2019; 392(6): 685.     CrossRef
  • Therapeutic experience of saxagliptin as first add-on after metformin in Indian type 2 diabetes patients: A non-interventional, prospective, observational study (ONTARGET-INDIA)
    Sanjay Kalra, Sarita Bajaj, AG Unnikrishnan, ManashP Baruah, Rakesh Sahay, V Hardik, Amit Kumar
    Indian Journal of Endocrinology and Metabolism.2019; 23(3): 312.     CrossRef
  • Cardiovascular Outcome Trials of the Incretin-Based Therapies: What Do We Know So Far?
    Pablo F. Mora, Eric L. Johnson
    Endocrine Practice.2017; 23(1): 89.     CrossRef
  • Treatment of Dyslipidemias to Prevent Cardiovascular Disease in Patients with Type 2 Diabetes
    Maryam Khavandi, Francisco Duarte, Henry N. Ginsberg, Gissette Reyes-Soffer
    Current Cardiology Reports.2017;[Epub]     CrossRef
  • Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters
    Eun-Sol Lee, Dong-Sung Lee, Prakash Raj Pandeya, Youn-Chul Kim, Dae-Gil Kang, Ho-Sub Lee, Byung-Chul Oh, Dae Ho Lee
    The Korean Journal of Physiology & Pharmacology.2017; 21(5): 519.     CrossRef
  • Risk of Myopathy Associated With DPP-4 Inhibitors in Combination With Statins: A Disproportionality Analysis Using Data From the WHO and French Spontaneous Reporting Databases
    Vanessa Labat, Mickael Arnaud, Ghada Miremont-Salamé, Francesco Salvo, Bernard Bégaud, Antoine Pariente
    Diabetes Care.2017; 40(3): e27.     CrossRef
  • Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate
    Dong-Sung Lee, Eun-Sol Lee, Md. Morshedul Alam, Jun-Hyeog Jang, Ho-Sub Lee, Hyuncheol Oh, Youn-Chul Kim, Zahid Manzoor, Young-Sang Koh, Dae-Gil Kang, Dae Ho Lee
    Metabolism.2016; 65(2): 89.     CrossRef
  • A Multifactorial Approach to Reduce Cardiovascular Disease in Type 2 Diabetes Mellitus: Now More Than Ever
    Jan N. Basile
    Hospital Practice.2016; 44(1): 9.     CrossRef
  • Association between DPP4 gene polymorphism and serum lipid levels in Chinese type 2 diabetes individuals
    Xiaomin Xing, Yi Han, Xiaojun Zhou, Bo Zhang, Yan Li, Zhongsu Wang, Lin Liao, Lequn Su
    Neuropeptides.2016; 60: 1.     CrossRef
  • Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile?
    Paul D. Rosenblit
    Cardiovascular Diabetology.2016;[Epub]     CrossRef
  • Dipeptidyl peptidase-4 inhibition and narrow-band ultraviolet-B light in psoriasis (DINUP): study protocol for a randomised controlled trial
    Maeve Lynch, Tomás B. Ahern, Irene Timoney, Cheryl Sweeney, Genevieve Kelly, Rosalind Hughes, Anne-Marie Tobin, Donal O’Shea, Brian Kirby
    Trials.2016;[Epub]     CrossRef
  • Efficacy of different dipeptidyl peptidase-4 (DPP-4) inhibitors on metabolic parameters in patients with type 2 diabetes undergoing dialysis
    Se Hee Park, Joo Young Nam, Eugene Han, Yong-ho Lee, Byung-Wan Lee, Beom Seok Kim, Bong-Soo Cha, Chul Sik Kim, Eun Seok Kang
    Medicine.2016; 95(32): e4543.     CrossRef
  • Incretin-based therapies for obesity treatment
    Aline Haas de Mello, Morgana Prá, Larissa Colonetti Cardoso, Rosiane de Bona Schraiber, Gislaine Tezza Rezin
    Metabolism.2015; 64(9): 967.     CrossRef
  • Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases
    Alexander O Shpakov, Kira V Derkach, Lev M Berstein
    Future Science OA.2015;[Epub]     CrossRef
  • Comparative analysis of therapeutic efficiency and costs (experience in Bulgaria) of oral antidiabetic therapies based on glitazones and gliptins
    Elena Pavlova Filipova, Katya Hristova Uzunova, Toni Yonkov Vekov
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug
    Mennatallah A. Ali, Hanan S. El-Abhar, Maher A. Kamel, Ahmed S. Attia, John Calvert
    PLOS ONE.2015; 10(8): e0134648.     CrossRef
  • The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors
    Na-Hyung Kim, Taeyang Yu, Dae Ho Lee
    BioMed Research International.2014; 2014: 1.     CrossRef
  • A Post Hoc Analysis of HbA1c, Hypoglycemia, and Weight Change Outcomes with Alogliptin vs Glipizide in Older Patients with Type 2 Diabetes
    Morgan Bron, Craig Wilson, Penny Fleck
    Diabetes Therapy.2014; 5(2): 521.     CrossRef
  • Response: The Effect of DPP-4 Inhibitors on Metabolic Parameters in Patients with Type 2 Diabetes (Diabetes Metab J2014;38:211-9)
    EunYeong Choe, Eun Seok Kang
    Diabetes & Metabolism Journal.2014; 38(4): 319.     CrossRef
  • Letter: The Effect of DPP-4 Inhibitors on Metabolic Parameters in Patients with Type 2 Diabetes (Diabetes Metab J2014;38:211-9)
    Seung-Hwan Lee
    Diabetes & Metabolism Journal.2014; 38(4): 317.     CrossRef
Glycemic Effectiveness of Metformin-Based Dual-Combination Therapies with Sulphonylurea, Pioglitazone, or DPP4-Inhibitor in Drug-Naïve Korean Type 2 Diabetic Patients
Young Ki Lee, Sun Ok Song, Kwang Joon Kim, Yongin Cho, Younjeong Choi, Yujung Yun, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee
Diabetes Metab J. 2013;37(6):465-474.   Published online December 12, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.6.465
  • 5,112 View
  • 67 Download
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

This study compared the glycemic effectiveness of three metformin-based dual therapies according to baseline hemoglobin A1c (HbA1c) to evaluate the appropriateness of the guideline enforced by the National Health Insurance Corporation of Korea for initial medication of type 2 diabetes (T2D).

Methods

This prospective observational study was conducted across 24 weeks for drug-naïve Korean T2D patients with HbA1c greater than 7.5%. Subjects were first divided into three groups based on the agent combined with metformin (group 1, gliclazide-modified release or glimepiride; group 2, pioglitazone; group 3, sitagliptin). Subjects were also classified into three categories according to baseline HbA1c (category I, 7.5%≤HbA1c<9.0%; category II, 9.0%≤HbA1c<11.0%; category III, 11.0%≤HbA1c).

Results

Among 116 subjects, 99 subjects completed the study, with 88 subjects maintaining the initial medication. While each of the metformin-based dual therapies showed a significant decrease in HbA1c (group 1, 8.9% to 6.4%; group 2, 9.0% to 6.6%; group 3, 9.3% to 6.3%; P<0.001 for each), there was no significant difference in the magnitude of HbA1c change among the groups. While the three HbA1c categories showed significantly different baseline HbA1c levels (8.2% vs. 9.9% vs. 11.9%; P<0.001), endpoint HbA1c was not different (6.4% vs. 6.6% vs. 6.0%; P=0.051).

Conclusion

The three dual therapies using a combination of metformin and either sulfonylurea, pioglitazone, or sitagliptin showed similar glycemic effectiveness among drug-naïve Korean T2D patients. In addition, these regimens were similarly effective across a wide range of baseline HbA1c levels.

Citations

Citations to this article as recorded by  
  • Benefits and risks of drug combination therapy for diabetes mellitus and its complications: a comprehensive review
    Xueqin Xie, Changchun Wu, Yuduo Hao, Tianyu Wang, Yuhe Yang, Peiling Cai, Yang Zhang, Jian Huang, Kejun Deng, Dan Yan, Hao Lin
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Estimation of Serum Creatinine, Aspartate Aminotransferase, Alanine Transaminase, and Hemoglobin A1c% Levels among Diabetic Patients using Metformin/Dipeptide Peptidase-4 Inhibitor Combination and Insulin – A Cross-Sectional Study
    Arshiya Shadab, Ilma Hussain, Praveen Kumar Kandakurti, Marwan Ismail, Ahmed Luay Osman Hashim, Salah Eldin Omar Hussein, Altoum Abd Elgadir
    Open Access Macedonian Journal of Medical Sciences.2022; 10(B): 959.     CrossRef
  • Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
    Hae Kyung Yang, Seung-Hwan Lee, Juyoung Shin, Yoon-Hee Choi, Yu-Bae Ahn, Byung-Wan Lee, Eun Jung Rhee, Kyung Wan Min, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2019; 43(3): 287.     CrossRef
  • Initial combination therapy with vildagliptin plus metformin in drug-naïve patients with T2DM: a 24-week real-life study from Asia
    Manoj Chawla, Tae Ho Kim, Roberto C. Mirasol, Pathan Faruque, Kathryn Cooke, Peggy Hours-Zesiger, Abhijit Shete
    Current Medical Research and Opinion.2018; 34(9): 1605.     CrossRef
  • Consensus recommendations on sulfonylurea and sulfonylurea combinations in the management of Type 2 diabetes mellitus – International Task Force
    Sanjay Kalra, Silver Bahendeka, Rakesh Sahay, Sujoy Ghosh, Fariduddin Md, Abbas Orabi, Kaushik Ramaiya, Sameer Al Shammari, Dina Shrestha, Khalid Shaikh, Sachitha Abhayaratna, PradeepK Shrestha, Aravinthan Mahalingam, Mazen Askheta, AlyAhmed A. Rahim, Fat
    Indian Journal of Endocrinology and Metabolism.2018; 22(1): 132.     CrossRef
  • Efficacy and safety of sitagliptin/metformin fixed‐dose combination compared with glimepiride in patients with type 2 diabetes: A multicenter randomized double‐blind study
    Sang Soo Kim, In Joo Kim, Kwang Jae Lee, Jeong Hyun Park, Young Il Kim, Young Sil Lee, Sung Chang Chung, Sang Jin Lee
    Journal of Diabetes.2017; 9(4): 412.     CrossRef
  • Short‐term intensive insulin therapy could be the preferred option for new onset Type 2 diabetes mellitus patients with HbA1c > 9%
    Jianping Weng
    Journal of Diabetes.2017; 9(10): 890.     CrossRef
  • The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus
    Gyuri Kim, Sewon Oh, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Moon-Kyu Lee
    Expert Opinion on Pharmacotherapy.2017; 18(12): 1179.     CrossRef
  • Effects of pioglitazone therapy on blood parameters, weight and BMI: a meta-analysis
    Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
    Diabetology & Metabolic Syndrome.2017;[Epub]     CrossRef
  • Is insulin the preferred treatment for HbA1c >9%?
    Zachary Bloomgarden
    Journal of Diabetes.2017; 9(9): 814.     CrossRef
  • The effect of pioglitazone on weight, lipid profile and liver enzymes in type 2 diabetic patients
    Nasser Aghamohammadzadeh, Mitra Niafar, Elham Dalir Abdolahinia, Farzad Najafipour, Saeed Mohamadzadeh Gharebaghi, Khadijeh Adabi, Elaheh Dalir Abdolahinia, Hamidreza Ahadi
    Therapeutic Advances in Endocrinology and Metabolism.2015; 6(2): 56.     CrossRef
  • Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1cwith Time
    Hye-jin Yoon, Yong-ho Lee, Kwang Joon Kim, So Ra Kim, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Byung-Wan Lee
    BioMed Research International.2015; 2015: 1.     CrossRef
  • Four-Year Durability of Initial Combination Therapy with Sitagliptin and Metformin in Patients with Type 2 Diabetes in Clinical Practice; COSMIC Study
    Eu Jeong Ku, Kyong Yeon Jung, Yoon Ji Kim, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Young Min Cho, Kyong Soo Park, Hak Chul Jang, Soo Lim, Bo Ahrén, Giorgio Sesti
    PLOS ONE.2015; 10(6): e0129477.     CrossRef
  • Comparative analysis of therapeutic efficiency and costs (experience in Bulgaria) of oral antidiabetic therapies based on glitazones and gliptins
    Elena Pavlova Filipova, Katya Hristova Uzunova, Toni Yonkov Vekov
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition
    Sen Shi, Swayam Prakash Srivastava, Megumi Kanasaki, Jianhua He, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Susumu Takagi, Keizo Kanasaki, Daisuke Koya
    Kidney International.2015; 88(3): 479.     CrossRef
  • Sodium Glucose Co-transporter 2 (SGLT2) Inhibitors: New among Antidiabetic Drugs
    L. H. Opie
    Cardiovascular Drugs and Therapy.2014; 28(4): 331.     CrossRef
  • Metformin Based Dual-Combination Therapies in Drug Naïve Type 2 Diabetic Patients
    Dong-Lim Kim
    Diabetes & Metabolism Journal.2013; 37(6): 429.     CrossRef
Diabetes Metab J : Diabetes & Metabolism Journal
© Korean Diabetes Association.
Email address
Sign up for the DMJ newsletter—
what matters in science, free to your inbox daily.